Colorectal Cancer

Roland P. Kuiper, Robbert D.A. Weren, Ad Geurts van Kessel

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)

Abstract

The development of colorectal cancer (CRC) is a multistep process, starting from benign precursor lesions in the epithelium of the colon or rectum, referred to as polyps, that have the potential to evolve in colorectal carcinomas by the sequential acquisition of specific genetic alterations. Hereditary genetic factors play a major role in the onset of CRC, and approximately 5% of CRCs can be explained by germ line mutations in one of the high-penetrance CRC predisposing genes. Early detection of mutations in CRC predisposing genes greatly facilitates cancer prevention and clinical decision-making in patients and families at risk. In this chapter, we will outline the current status and directions in CRC susceptibility research and discuss their implications.

Original languageEnglish
Title of host publicationGenomic and Precision Medicine
Subtitle of host publicationPrimary Care: Third Edition
PublisherElsevier Inc.
Pages195-209
Number of pages15
ISBN (Electronic)9780128006542
ISBN (Print)9780128006856
DOIs
Publication statusPublished - 23 Mar 2017

Keywords

  • APC
  • Colorectal cancer
  • CRC syndromes
  • MUTYH
  • NTHL1
  • Polyposis

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