Combination treatment with somatostatin analogues and pegvisomant in acromegaly

S. J.C.M.M. Neggers, A. J. Van Der Lely

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54 Citations (Scopus)

Abstract

Mono-therapy using long-acting somatostatin analogues and surgery cannot provide optimal biochemical control in a large proportion of patients with acromegaly. This results in increased mortality, poor control of signs and symptoms of disease and decreased quality of life. Combined treatment with somatostatin analogues and pegvisomant (a growth-hormone-receptor antagonist) seems to be an attractive option. Combination treatment is highly effective at normalising the level of insulin-like growth factor 1 in over 90% of patients and has a favourable effect on quality of life in those with biochemically controlled acromegaly. Moreover, combination therapy with somatostatin analogues results in a clinically relevant decrease in tumour size in about 20% of patients, whereas pegvisomant (PEG-V) mono-therapy does not decrease pituitary tumour size. Transient elevations in the levels of transaminases are the main adverse effects of combination treatment, which occur in about 11-15% of patients.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalGrowth Hormone and IGF Research
Volume21
Issue number3
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Keywords

  • Acromegaly
  • Pegvisomant
  • Pituitary
  • Somatostatin analogues

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