TY - JOUR
T1 - Combined Treatment of Colon Adenocarcinoma in Rats with Tumor Necrosis Factor and the Interferon Inducer ABPP
AU - Marquet, Richard L.
AU - Eggermont, Alexander M.m.
AU - de Bruin, Ron W.F.
AU - Fiers, Walter
AU - Jeekel, Johannes
PY - 1988/6
Y1 - 1988/6
N2 - It is well documented that the antitumor capacity of tumor necrosis factor (TNF) can be enhanced by interferons (IFNs), notably IFN-γ. The aim of this study was to investigate the efficacy of a combined treatment with TNF and the IFN-inducer 2-amino-5-bromo-6-phenyl-4-pyrimidinone (ABPP) on a transplantable colon carcinoma (CC531) in rats. The tumor was implanted under the kidney capsule of syngeneic rats; the tumors were removed a week after implantation and growth was assessed by weighing. The animals were treated with 1 μg of TNF, given i.v. on days 0, 2, and 4; and with 250 mg/kg of ABPP, administered i.p. on days 0 and 1. The results of two separate experiments indicated that both TNF and ABPP had a significant inhibitory effect on tumor growth. Combined, the two agents were found to act additively. In the dosage used, TNF toxicity was mild, transient, and not influenced by ABPP.
AB - It is well documented that the antitumor capacity of tumor necrosis factor (TNF) can be enhanced by interferons (IFNs), notably IFN-γ. The aim of this study was to investigate the efficacy of a combined treatment with TNF and the IFN-inducer 2-amino-5-bromo-6-phenyl-4-pyrimidinone (ABPP) on a transplantable colon carcinoma (CC531) in rats. The tumor was implanted under the kidney capsule of syngeneic rats; the tumors were removed a week after implantation and growth was assessed by weighing. The animals were treated with 1 μg of TNF, given i.v. on days 0, 2, and 4; and with 250 mg/kg of ABPP, administered i.p. on days 0 and 1. The results of two separate experiments indicated that both TNF and ABPP had a significant inhibitory effect on tumor growth. Combined, the two agents were found to act additively. In the dosage used, TNF toxicity was mild, transient, and not influenced by ABPP.
UR - http://www.scopus.com/inward/record.url?scp=0023940220&partnerID=8YFLogxK
U2 - 10.1089/jir.1988.8.319
DO - 10.1089/jir.1988.8.319
M3 - Article
C2 - 3411161
AN - SCOPUS:0023940220
SN - 0197-8357
VL - 8
SP - 319
EP - 323
JO - Journal of Interferon Research
JF - Journal of Interferon Research
IS - 3
ER -