TY - JOUR
T1 - Complementary and alternative medicine modalities used to treat adverse effects of anti-cancer treatment among children and young adults
T2 - a systematic review and meta-analysis of randomized controlled trials
AU - Mora, Dana C.
AU - Overvåg, Grete
AU - Jong, Miek C.
AU - Kristoffersen, Agnete E.
AU - Stavleu, Debbie C.
AU - Liu, Jianping
AU - Stub, Trine
N1 - © 2022. The Author(s).
PY - 2022/4/2
Y1 - 2022/4/2
N2 - BACKGROUND: Dealing with the symptom burden of cancer diagnosis and treatment has led parents to seek different self-management strategies including Alternative and Complementary Medicine (CAM). The aim of this study was to perform a systematic review and meta-analysis about the use and effect of CAM modalities to treat adverse effects of conventional cancer treatment among children and young adults.METHODS: Six scientific research databases were used to identify randomized controlled trials (RCTs) from 1990 to September 2020. Included studies investigated the use of CAM to treat cancer treatment related adverse effects in children and young adults compared to controls.RESULTS: Twenty RCTs comprising 1,069 participants were included in this review. The included studies investigated acupuncture, mind-body therapies, supplements, and vitamins for chemotherapy-induced nausea and vomiting (CINV), oral mucositis, and anxiety among children and young adults who underwent conventional cancer treatment. Seven studies (315 participants) were included in the meta-analysis. The overall effect of CAM (including acupuncture and hypnosis only) on chemotherapy-induced nausea and/or vomiting and controls was statistically significant with a standard mean difference of -0.54, 95% CI [-0.77, -0.31] I
2 = 0% (p < 0.00001). There was a significant difference between acupuncture and controls (n = 5) for intensity and/or episodes of CINV with an SMD -0.59, 95% CI [-0.85, -0.33] (p < 0.00001). No significant difference was found between hypnosis and controls (n = 2) for severity or episodes of CINV with an SMD -0.41, 95% CI [-1.09, 0.27] I
2 = 41% (p = 0.19).
CONCLUSION: Current evidence from this meta-analysis of randomized controlled trials shows that CAM, including acupuncture and hypnosis only, is effective in reducing chemotherapy-induced nausea and vomiting in children and young adults. More rigorous trials and long-term effects should be investigated if acupuncture and hypnosis are to be recommended for clinical use.
AB - BACKGROUND: Dealing with the symptom burden of cancer diagnosis and treatment has led parents to seek different self-management strategies including Alternative and Complementary Medicine (CAM). The aim of this study was to perform a systematic review and meta-analysis about the use and effect of CAM modalities to treat adverse effects of conventional cancer treatment among children and young adults.METHODS: Six scientific research databases were used to identify randomized controlled trials (RCTs) from 1990 to September 2020. Included studies investigated the use of CAM to treat cancer treatment related adverse effects in children and young adults compared to controls.RESULTS: Twenty RCTs comprising 1,069 participants were included in this review. The included studies investigated acupuncture, mind-body therapies, supplements, and vitamins for chemotherapy-induced nausea and vomiting (CINV), oral mucositis, and anxiety among children and young adults who underwent conventional cancer treatment. Seven studies (315 participants) were included in the meta-analysis. The overall effect of CAM (including acupuncture and hypnosis only) on chemotherapy-induced nausea and/or vomiting and controls was statistically significant with a standard mean difference of -0.54, 95% CI [-0.77, -0.31] I
2 = 0% (p < 0.00001). There was a significant difference between acupuncture and controls (n = 5) for intensity and/or episodes of CINV with an SMD -0.59, 95% CI [-0.85, -0.33] (p < 0.00001). No significant difference was found between hypnosis and controls (n = 2) for severity or episodes of CINV with an SMD -0.41, 95% CI [-1.09, 0.27] I
2 = 41% (p = 0.19).
CONCLUSION: Current evidence from this meta-analysis of randomized controlled trials shows that CAM, including acupuncture and hypnosis only, is effective in reducing chemotherapy-induced nausea and vomiting in children and young adults. More rigorous trials and long-term effects should be investigated if acupuncture and hypnosis are to be recommended for clinical use.
KW - Adverse effects
KW - Chemotherapy-induced nausea and vomiting (CINV)
KW - Complementary and alternative medicine (CAM)
KW - Pediatric oncology
KW - Young Adult
KW - Complementary Therapies
KW - Vomiting/chemically induced
KW - Nausea/chemically induced
KW - Drug-Related Side Effects and Adverse Reactions
KW - Humans
KW - Child
KW - Randomized Controlled Trials as Topic
KW - Adverse effects
KW - Chemotherapy-induced nausea and vomiting (CINV)
KW - Complementary and alternative medicine (CAM)
KW - Pediatric oncology
UR - http://www.scopus.com/inward/record.url?scp=85127480949&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/010c09b8-7cc6-328f-a8ed-b0134544a399/
U2 - 10.1186/s12906-022-03537-w
DO - 10.1186/s12906-022-03537-w
M3 - Article
C2 - 35366871
AN - SCOPUS:85127480949
SN - 2662-7671
VL - 22
SP - 97
JO - BMC Complementary Medicine and Therapies
JF - BMC Complementary Medicine and Therapies
IS - 1
M1 - 97
ER -