Consensus on acromegaly complications: an update

Andrea Giustina; Luigi di Filippo; Maria Fleseriu; Rosario Pivonello; Stephan Petersenn; John Wass; Susan L. Samson; Alberto M. Pereira; Raúl M. Luque; Betina Biagetti; Maria Chiara Zatelli; Ken K.Y. Ho; Cesar L. Boguszewski; Aart Jan van der Lely; Mark Gurnell; Nienke Biermasz; Katharina Schilbach; Diego Ferone; Monica R. Gadelha; Adriana G. Ioachimescu; Ezio Ghigo; Christian J. Strasburger; Pinar Kadioglu; Pietro Maffei; Niki Karavitaki; Mónica Marazuela; Michael Buchfelder; Sabrina Chiloiro; Anton Luger; Yona Greenman; Elena Valassi; Ignacio Bernabeu; Stefano Frara; Philippe Chanson; Thierry Brue; John Ayuk; Felipe F. Casanueva; Annamaria Colao; Pietro Mortini; Sebastian Neggers; Manel Puig-Domingo; Meliha Melin Uygur; Shlomo Melmed

doi:10.1007/s11102-026-01639-z

Consensus on acromegaly complications: an update

Andrea Giustina
, Luigi di Filippo
, Maria Fleseriu
, Rosario Pivonello
, Stephan Petersenn
, John Wass
, Susan L. Samson
, Alberto M. Pereira
, Raúl M. Luque
, Betina Biagetti
, Maria Chiara Zatelli
, Ken K.Y. Ho
, Cesar L. Boguszewski
, Aart Jan van der Lely
, Mark Gurnell
, Nienke Biermasz
, Katharina Schilbach
, Diego Ferone
, Monica R. Gadelha
, Adriana G. Ioachimescu

Ezio Ghigo, Christian J. Strasburger, Pinar Kadioglu, Pietro Maffei, Niki Karavitaki, Mónica Marazuela, Michael Buchfelder, Sabrina Chiloiro, Anton Luger, Yona Greenman, Elena Valassi, Ignacio Bernabeu, Stefano Frara, Philippe Chanson, Thierry Brue, John Ayuk, Felipe F. Casanueva, Annamaria Colao, Pietro Mortini, Sebastian Neggers, Manel Puig-Domingo, Meliha Melin Uygur, Shlomo Melmed

Research output: Contribution to journal › Review article › peer-review

Abstract

The 16th Acromegaly Consensus Conference in September 2024 updated recommendations on diagnosis and treatment of acromegaly comorbidities. Since the 2020 acromegaly comorbidity management guideline was published, new evidence has emerged on novel and known comorbidities and new treatment approaches. Forty-three experts in the management of acromegaly reviewed the current literature and assessed changes in clinical practice standards and management. Current outcome goals were considered and updated, with a focus on the impact of current and emerging treatments of these comorbidities. Participants assessed factors that determine pharmacological choices, as well as use of specific agents in the management of the most relevant acromegaly comorbidities. We present consensus recommendations highlighting optimization of evidence-based acromegaly comorbidities management.

Original language	English
Article number	76
Journal	Pituitary
Volume	29
Issue number	3
DOIs	https://doi.org/10.1007/s11102-026-01639-z
Publication status	Published - Jun 2026
Externally published	Yes

Keywords

Acral changes
Arthritis
Diabetes
GH receptor antagonist
Growth hormone
Hypertension
IGF1
Pituitary adenoma
Somatostatin receptor ligand
Transpenoidal surgery

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10.1007/s11102-026-01639-z

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Giustina, A., di Filippo, L., Fleseriu, M., Pivonello, R., Petersenn, S., Wass, J., Samson, S. L., Pereira, A. M., Luque, R. M., Biagetti, B., Zatelli, M. C., Ho, K. K. Y., Boguszewski, C. L., van der Lely, A. J., Gurnell, M., Biermasz, N., Schilbach, K., Ferone, D., Gadelha, M. R., ... Melmed, S. (2026). Consensus on acromegaly complications: an update. Pituitary, 29(3), Article 76. https://doi.org/10.1007/s11102-026-01639-z

@article{68620b2c78814ad6b29146a14cc2baa2,

title = "Consensus on acromegaly complications: an update",

abstract = "The 16th Acromegaly Consensus Conference in September 2024 updated recommendations on diagnosis and treatment of acromegaly comorbidities. Since the 2020 acromegaly comorbidity management guideline was published, new evidence has emerged on novel and known comorbidities and new treatment approaches. Forty-three experts in the management of acromegaly reviewed the current literature and assessed changes in clinical practice standards and management. Current outcome goals were considered and updated, with a focus on the impact of current and emerging treatments of these comorbidities. Participants assessed factors that determine pharmacological choices, as well as use of specific agents in the management of the most relevant acromegaly comorbidities. We present consensus recommendations highlighting optimization of evidence-based acromegaly comorbidities management.",

keywords = "Acral changes, Arthritis, Diabetes, GH receptor antagonist, Growth hormone, Hypertension, IGF1, Pituitary adenoma, Somatostatin receptor ligand, Transpenoidal surgery",

author = "Andrea Giustina and \{di Filippo\}, Luigi and Maria Fleseriu and Rosario Pivonello and Stephan Petersenn and John Wass and Samson, \{Susan L.\} and Pereira, \{Alberto M.\} and Luque, \{Ra{\'u}l M.\} and Betina Biagetti and Zatelli, \{Maria Chiara\} and Ho, \{Ken K.Y.\} and Boguszewski, \{Cesar L.\} and \{van der Lely\}, \{Aart Jan\} and Mark Gurnell and Nienke Biermasz and Katharina Schilbach and Diego Ferone and Gadelha, \{Monica R.\} and Ioachimescu, \{Adriana G.\} and Ezio Ghigo and Strasburger, \{Christian J.\} and Pinar Kadioglu and Pietro Maffei and Niki Karavitaki and M{\'o}nica Marazuela and Michael Buchfelder and Sabrina Chiloiro and Anton Luger and Yona Greenman and Elena Valassi and Ignacio Bernabeu and Stefano Frara and Philippe Chanson and Thierry Brue and John Ayuk and Casanueva, \{Felipe F.\} and Annamaria Colao and Pietro Mortini and Sebastian Neggers and Manel Puig-Domingo and Uygur, \{Meliha Melin\} and Shlomo Melmed",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2026.",

year = "2026",

month = jun,

doi = "10.1007/s11102-026-01639-z",

language = "English",

volume = "29",

journal = "Pituitary",

issn = "1386-341X",

publisher = "Springer",

number = "3",

}

Giustina, A, di Filippo, L, Fleseriu, M, Pivonello, R, Petersenn, S, Wass, J, Samson, SL, Pereira, AM, Luque, RM, Biagetti, B, Zatelli, MC, Ho, KKY, Boguszewski, CL, van der Lely, AJ, Gurnell, M, Biermasz, N, Schilbach, K, Ferone, D, Gadelha, MR, Ioachimescu, AG, Ghigo, E, Strasburger, CJ, Kadioglu, P, Maffei, P, Karavitaki, N, Marazuela, M, Buchfelder, M, Chiloiro, S, Luger, A, Greenman, Y, Valassi, E, Bernabeu, I, Frara, S, Chanson, P, Brue, T, Ayuk, J, Casanueva, FF, Colao, A, Mortini, P, Neggers, S, Puig-Domingo, M, Uygur, MM & Melmed, S 2026, 'Consensus on acromegaly complications: an update', Pituitary, vol. 29, no. 3, 76. https://doi.org/10.1007/s11102-026-01639-z

TY - JOUR

T1 - Consensus on acromegaly complications

T2 - an update

AU - Giustina, Andrea

AU - di Filippo, Luigi

AU - Fleseriu, Maria

AU - Pivonello, Rosario

AU - Petersenn, Stephan

AU - Wass, John

AU - Samson, Susan L.

AU - Pereira, Alberto M.

AU - Luque, Raúl M.

AU - Biagetti, Betina

AU - Zatelli, Maria Chiara

AU - Ho, Ken K.Y.

AU - Boguszewski, Cesar L.

AU - van der Lely, Aart Jan

AU - Gurnell, Mark

AU - Biermasz, Nienke

AU - Schilbach, Katharina

AU - Ferone, Diego

AU - Gadelha, Monica R.

AU - Ioachimescu, Adriana G.

AU - Ghigo, Ezio

AU - Strasburger, Christian J.

AU - Kadioglu, Pinar

AU - Maffei, Pietro

AU - Karavitaki, Niki

AU - Marazuela, Mónica

AU - Buchfelder, Michael

AU - Chiloiro, Sabrina

AU - Luger, Anton

AU - Greenman, Yona

AU - Valassi, Elena

AU - Bernabeu, Ignacio

AU - Frara, Stefano

AU - Chanson, Philippe

AU - Brue, Thierry

AU - Ayuk, John

AU - Casanueva, Felipe F.

AU - Colao, Annamaria

AU - Mortini, Pietro

AU - Neggers, Sebastian

AU - Puig-Domingo, Manel

AU - Uygur, Meliha Melin

AU - Melmed, Shlomo

PY - 2026/6

Y1 - 2026/6

N2 - The 16th Acromegaly Consensus Conference in September 2024 updated recommendations on diagnosis and treatment of acromegaly comorbidities. Since the 2020 acromegaly comorbidity management guideline was published, new evidence has emerged on novel and known comorbidities and new treatment approaches. Forty-three experts in the management of acromegaly reviewed the current literature and assessed changes in clinical practice standards and management. Current outcome goals were considered and updated, with a focus on the impact of current and emerging treatments of these comorbidities. Participants assessed factors that determine pharmacological choices, as well as use of specific agents in the management of the most relevant acromegaly comorbidities. We present consensus recommendations highlighting optimization of evidence-based acromegaly comorbidities management.

AB - The 16th Acromegaly Consensus Conference in September 2024 updated recommendations on diagnosis and treatment of acromegaly comorbidities. Since the 2020 acromegaly comorbidity management guideline was published, new evidence has emerged on novel and known comorbidities and new treatment approaches. Forty-three experts in the management of acromegaly reviewed the current literature and assessed changes in clinical practice standards and management. Current outcome goals were considered and updated, with a focus on the impact of current and emerging treatments of these comorbidities. Participants assessed factors that determine pharmacological choices, as well as use of specific agents in the management of the most relevant acromegaly comorbidities. We present consensus recommendations highlighting optimization of evidence-based acromegaly comorbidities management.

KW - Acral changes

KW - Arthritis

KW - Diabetes

KW - GH receptor antagonist

KW - Growth hormone

KW - Hypertension

KW - IGF1

KW - Pituitary adenoma

KW - Somatostatin receptor ligand

KW - Transpenoidal surgery

UR - https://www.scopus.com/pages/publications/105037425082

U2 - 10.1007/s11102-026-01639-z

DO - 10.1007/s11102-026-01639-z

M3 - Review article

C2 - 42050227

AN - SCOPUS:105037425082

SN - 1386-341X

VL - 29

JO - Pituitary

JF - Pituitary

IS - 3

M1 - 76

ER -

Consensus on acromegaly complications: an update

Abstract

Keywords

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