Controlled assembly of macromolecular β-sheet fibrils

Jurgen M. Smeenk; Matthijs B.J. Otten; Jens Thies; David A. Tirrell; Hendrik G. Stunnenberg; Jan C.M. Van Hest

doi:10.1002/anie.200462415

Controlled assembly of macromolecular β-sheet fibrils

Jurgen M. Smeenk
, Matthijs B.J. Otten
, Jens Thies
, David A. Tirrell
, Hendrik G. Stunnenberg
, Jan C.M. Van Hest

Research output: Contribution to journal › Article › peer-review

145 Citations (Scopus)

Abstract

Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)₃GluGly] _n sequence and poly(ethylene glycol) (PEG) of M_n = 750 g mol^-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).

Original language	English
Pages (from-to)	1968-1971
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	13
DOIs	https://doi.org/10.1002/anie.200462415
Publication status	Published - 18 Mar 2005
Externally published	Yes

Keywords

Conjugation
Fibers
Peptides
Polymers
Self-assembly

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10.1002/anie.200462415

Cite this

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title = "Controlled assembly of macromolecular β-sheet fibrils",

abstract = "Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly] n sequence and poly(ethylene glycol) (PEG) of Mn = 750 g mol-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).",

keywords = "Conjugation, Fibers, Peptides, Polymers, Self-assembly",

author = "Smeenk, \{Jurgen M.\} and Otten, \{Matthijs B.J.\} and Jens Thies and Tirrell, \{David A.\} and Stunnenberg, \{Hendrik G.\} and \{Van Hest\}, \{Jan C.M.\}",

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T1 - Controlled assembly of macromolecular β-sheet fibrils

AU - Smeenk, Jurgen M.

AU - Otten, Matthijs B.J.

AU - Thies, Jens

AU - Tirrell, David A.

AU - Stunnenberg, Hendrik G.

AU - Van Hest, Jan C.M.

PY - 2005/3/18

Y1 - 2005/3/18

N2 - Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly] n sequence and poly(ethylene glycol) (PEG) of Mn = 750 g mol-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).

AB - Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly] n sequence and poly(ethylene glycol) (PEG) of Mn = 750 g mol-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).

KW - Conjugation

KW - Fibers

KW - Peptides

KW - Polymers

KW - Self-assembly

UR - https://www.scopus.com/pages/publications/16844369868

U2 - 10.1002/anie.200462415

DO - 10.1002/anie.200462415

M3 - Article

C2 - 15724260

AN - SCOPUS:16844369868

SN - 1433-7851

VL - 44

SP - 1968

EP - 1971

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 13

ER -

Controlled assembly of macromolecular β-sheet fibrils

Abstract

Keywords

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