Cytogenetic Analysis of Murine Embryo-derived Tumors

R. J. van Berlo; B. de Jong; J. W. Oosterhuis; T. Dijkhuizen; J. Buist; A. Dam

Cytogenetic Analysis of Murine Embryo-derived Tumors

R. J. van Berlo
, B. de Jong
, J. W. Oosterhuis
, T. Dijkhuizen
, J. Buist
, A. Dam

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The possible relationship among malignancy, differentiation, and chromosomal constitution of primary embryo-derived tumors was studied. Tumors were induced by transplanting 7-day-old mouse embryos under the kidney capsule of syngeneic BALB/c recipients. Transplantation of 101 embryos resulted in 81 tumor-bearing mice: 36 teratocarcinomas; 18 teratomas; and 27 yolk sac tumors. Some of the yolk sac tumors proved to be retransplantable for several generations. Cytogenetic investigation of the primary embryo-derived tumors revealed that the majority of teratocarcinomas (82%) were chromosomally normal, whereas almost all (83%) karyotyped teratomas and yolk sac tumors had a highly abnormal chromosomal constitution. Most common aberrations were polyploidy; overrepresentation of chromosome 1, 6,15, or 19; and an underrepresentation of chromosome 2, 4, 14, or a sex chromosome.

Original language	English
Pages (from-to)	3416-3421
Number of pages	6
Journal	Cancer Research
Volume	50
Issue number	11
Publication status	Published - 1 Jun 1990
Externally published	Yes

Cite this

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title = "Cytogenetic Analysis of Murine Embryo-derived Tumors",

abstract = "The possible relationship among malignancy, differentiation, and chromosomal constitution of primary embryo-derived tumors was studied. Tumors were induced by transplanting 7-day-old mouse embryos under the kidney capsule of syngeneic BALB/c recipients. Transplantation of 101 embryos resulted in 81 tumor-bearing mice: 36 teratocarcinomas; 18 teratomas; and 27 yolk sac tumors. Some of the yolk sac tumors proved to be retransplantable for several generations. Cytogenetic investigation of the primary embryo-derived tumors revealed that the majority of teratocarcinomas (82\%) were chromosomally normal, whereas almost all (83\%) karyotyped teratomas and yolk sac tumors had a highly abnormal chromosomal constitution. Most common aberrations were polyploidy; overrepresentation of chromosome 1, 6,15, or 19; and an underrepresentation of chromosome 2, 4, 14, or a sex chromosome.",

author = "\{van Berlo\}, \{R. J.\} and \{de Jong\}, B. and Oosterhuis, \{J. W.\} and T. Dijkhuizen and J. Buist and A. Dam",

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language = "English",

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T1 - Cytogenetic Analysis of Murine Embryo-derived Tumors

AU - van Berlo, R. J.

AU - de Jong, B.

AU - Oosterhuis, J. W.

AU - Dijkhuizen, T.

AU - Buist, J.

AU - Dam, A.

PY - 1990/6/1

Y1 - 1990/6/1

N2 - The possible relationship among malignancy, differentiation, and chromosomal constitution of primary embryo-derived tumors was studied. Tumors were induced by transplanting 7-day-old mouse embryos under the kidney capsule of syngeneic BALB/c recipients. Transplantation of 101 embryos resulted in 81 tumor-bearing mice: 36 teratocarcinomas; 18 teratomas; and 27 yolk sac tumors. Some of the yolk sac tumors proved to be retransplantable for several generations. Cytogenetic investigation of the primary embryo-derived tumors revealed that the majority of teratocarcinomas (82%) were chromosomally normal, whereas almost all (83%) karyotyped teratomas and yolk sac tumors had a highly abnormal chromosomal constitution. Most common aberrations were polyploidy; overrepresentation of chromosome 1, 6,15, or 19; and an underrepresentation of chromosome 2, 4, 14, or a sex chromosome.

AB - The possible relationship among malignancy, differentiation, and chromosomal constitution of primary embryo-derived tumors was studied. Tumors were induced by transplanting 7-day-old mouse embryos under the kidney capsule of syngeneic BALB/c recipients. Transplantation of 101 embryos resulted in 81 tumor-bearing mice: 36 teratocarcinomas; 18 teratomas; and 27 yolk sac tumors. Some of the yolk sac tumors proved to be retransplantable for several generations. Cytogenetic investigation of the primary embryo-derived tumors revealed that the majority of teratocarcinomas (82%) were chromosomally normal, whereas almost all (83%) karyotyped teratomas and yolk sac tumors had a highly abnormal chromosomal constitution. Most common aberrations were polyploidy; overrepresentation of chromosome 1, 6,15, or 19; and an underrepresentation of chromosome 2, 4, 14, or a sex chromosome.

UR - https://www.scopus.com/pages/publications/0025340136

M3 - Article

C2 - 2334937

AN - SCOPUS:0025340136

SN - 0008-5472

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JO - Cancer Research

JF - Cancer Research

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ER -

Cytogenetic Analysis of Murine Embryo-derived Tumors

Abstract

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