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Cytogenetic classification of renal cell cancer

  • Eva Van den Berg
  • , T. Dijkhuizen
  • , J. Wolter Oosterhuis
  • , Ad Geurts Van Kessel
  • , Bauke De Jong
  • , Stephan Stö̈rkel

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

Cytogenetic and molecular genetic investigations in cancer are important tools to address problems of oncegenesis and tumor progression, of classification, and of diagnosis of tumors. A combination of advanced molecular genetic, cytogenetic, and (immuno) histopathologic analysis will contribute significantly to the elucidation of the oncogenic steps that lead to immortalization and subsequent malignant behavior. In this review written on the occasion of Dr. Avery Sandberg's 75th anniversary, we will present a model for the pathogenesis of renal cell tumors based on a new cytomorphologic classification and our (cyto)genetic analysis of about 175 renal cell tumors, together with the accumulation data in the litetature.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalCancer genetics and cytogenetics
Volume95
Issue number1
DOIs
Publication statusPublished - May 1997
Externally publishedYes

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