Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors

J van Echten, R J van Gurp, M Stoepker, L H Looijenga, J de Jong, W Oosterhuis

Research output: Contribution to journalArticlepeer-review

Abstract

A cytogenetic study of two cases of carcinoma in situ of the testis (CIS) and their adjacent invasive tumors, one a nonseminomatous germ cell tumor (NS) and one a seminoma (SE), revealed similarities in chromosomal pattern between the CIS and the invasive lesion in the same patient. These findings present for the first time cytogenetic evidence that CIS of the testis and its adjacent germ cell tumor are clonally related, which suggests that the CIS is indeed the precursor lesion of the invasive tumor.

Original languageEnglish
Pages (from-to)133-7
Number of pages5
JournalCancer genetics and cytogenetics
Volume85
Issue number2
DOIs
Publication statusPublished - Dec 1995
Externally publishedYes

Keywords

  • Adult
  • Carcinoma in Situ/genetics
  • Humans
  • Karyotyping
  • Male
  • Neoplasm Invasiveness
  • Teratoma/genetics
  • Testicular Neoplasms/genetics

Fingerprint

Dive into the research topics of 'Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors'. Together they form a unique fingerprint.

Cite this