TY - JOUR
T1 - Cytogenetics of 12 cases of renal adenocarcinoma
AU - de Jong, Bauke
AU - Oosterhuis, J. Wolter
AU - Idenburg, Vera J.S.
AU - Castedo, Sergio M.M.J.
AU - Dam, Anke
AU - Mensink, Han J.A.
N1 - Funding Information:
Supported by The Netherlands Cancer l:oundatiou, the Jan Korllelis de Cock Sticbtin!~, and the Stichting Kinderoncologie Groniugen. The authors thank Mentje Dijkstra for typing tim manuscript.
PY - 1988/1
Y1 - 1988/1
N2 - The cytogenetics of 12 cases of renal adenocarcinoma are presented. Clonal abnormalities were found in nine patients. Worth mentioning are abnormalities of the X chromosome (1 ×) and the chromosomes #1(3 ×), #3(3 ×), #7(4 ×), #8(4 ×), and #14(2 ×). From our data and data from the literature it appeared that the chromosomal regions 3p11-p21, 1q21, 14q22, and Xp11 are important for the oncogenesis of renal cell carcinoma as well as increased dosage of chromosome #7 and loss or abnormalities of chromosomes #8 and #14.
AB - The cytogenetics of 12 cases of renal adenocarcinoma are presented. Clonal abnormalities were found in nine patients. Worth mentioning are abnormalities of the X chromosome (1 ×) and the chromosomes #1(3 ×), #3(3 ×), #7(4 ×), #8(4 ×), and #14(2 ×). From our data and data from the literature it appeared that the chromosomal regions 3p11-p21, 1q21, 14q22, and Xp11 are important for the oncogenesis of renal cell carcinoma as well as increased dosage of chromosome #7 and loss or abnormalities of chromosomes #8 and #14.
UR - http://www.scopus.com/inward/record.url?scp=0023838928&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(88)90092-1
DO - 10.1016/0165-4608(88)90092-1
M3 - Article
C2 - 3422048
AN - SCOPUS:0023838928
SN - 0165-4608
VL - 30
SP - 53
EP - 61
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -