Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome

Bianca M.M. Streng; Marin Bont; Eveline M. Delemarre; Rob S. Binnendijk; Gaby Smit; Gerco Den Hartog; Antonia M.W. Coppus; Esther De Vries; Michel E. Weijerman; Regina Lamberts; Gert De Graaf; Fiona R. Van Der Klis; Gestur Vidarsson; Neele Rave; Louis J. Bont; Joanne G. Wildenbeest

doi:10.1093/infdis/jiac235

Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome

Bianca M.M. Streng
, Marin Bont
, Eveline M. Delemarre
, Rob S. Binnendijk
, Gaby Smit
, Gerco Den Hartog
, Antonia M.W. Coppus
, Esther De Vries
, Michel E. Weijerman
, Regina Lamberts
, Gert De Graaf
, Fiona R. Van Der Klis
, Gestur Vidarsson
, Neele Rave
, Louis J. Bont
, Joanne G. Wildenbeest

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age. Clinical Trials Registration: NCT05145348.

Original language	English
Pages (from-to)	673-677
Number of pages	5
Journal	The Journal of infectious diseases
Volume	226
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jiac235
Publication status	Published - 15 Aug 2022
Externally published	Yes

Keywords

antibody response
COVID-19 vaccination
Down syndrome
SARS-CoV-2
Prospective Studies
Humans
Vaccination
Antibodies, Viral
Down Syndrome
BNT162 Vaccine
COVID-19 Vaccines
Antibody Formation
Adult
COVID-19/prevention & control
RNA, Messenger

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Streng, B. M. M., Bont, M., Delemarre, E. M., Binnendijk, R. S., Smit, G., Den Hartog, G., Coppus, A. M. W., De Vries, E., Weijerman, M. E., Lamberts, R., De Graaf, G., Van Der Klis, F. R., Vidarsson, G., Rave, N., Bont, L. J., & Wildenbeest, J. G. (2022). Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome. The Journal of infectious diseases, 226(4), 673-677. https://doi.org/10.1093/infdis/jiac235

@article{d4fac0d3971d4b8c87c627a2d9cce1c7,

title = "Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome",

abstract = "The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age. Clinical Trials Registration: NCT05145348.",

keywords = "antibody response, COVID-19 vaccination, Down syndrome, SARS-CoV-2, Prospective Studies, Humans, Vaccination, Antibodies, Viral, Down Syndrome, BNT162 Vaccine, COVID-19 Vaccines, Antibody Formation, Adult, COVID-19/prevention \& control, RNA, Messenger",

author = "Streng, \{Bianca M.M.\} and Marin Bont and Delemarre, \{Eveline M.\} and Binnendijk, \{Rob S.\} and Gaby Smit and \{Den Hartog\}, Gerco and Coppus, \{Antonia M.W.\} and \{De Vries\}, Esther and Weijerman, \{Michel E.\} and Regina Lamberts and \{De Graaf\}, Gert and \{Van Der Klis\}, \{Fiona R.\} and Gestur Vidarsson and Neele Rave and Bont, \{Louis J.\} and Wildenbeest, \{Joanne G.\}",

note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2022",

month = aug,

day = "15",

doi = "10.1093/infdis/jiac235",

language = "English",

volume = "226",

pages = "673--677",

journal = "The Journal of infectious diseases",

issn = "1537-6613",

publisher = "Oxford University Press",

number = "4",

}

Streng, BMM, Bont, M, Delemarre, EM, Binnendijk, RS, Smit, G, Den Hartog, G, Coppus, AMW, De Vries, E, Weijerman, ME, Lamberts, R, De Graaf, G, Van Der Klis, FR, Vidarsson, G, Rave, N, Bont, LJ & Wildenbeest, JG 2022, 'Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome', The Journal of infectious diseases, vol. 226, no. 4, pp. 673-677. https://doi.org/10.1093/infdis/jiac235

TY - JOUR

T1 - Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome

AU - Streng, Bianca M.M.

AU - Bont, Marin

AU - Delemarre, Eveline M.

AU - Binnendijk, Rob S.

AU - Smit, Gaby

AU - Den Hartog, Gerco

AU - Coppus, Antonia M.W.

AU - De Vries, Esther

AU - Weijerman, Michel E.

AU - Lamberts, Regina

AU - De Graaf, Gert

AU - Van Der Klis, Fiona R.

AU - Vidarsson, Gestur

AU - Rave, Neele

AU - Bont, Louis J.

AU - Wildenbeest, Joanne G.

N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2022/8/15

Y1 - 2022/8/15

N2 - The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age. Clinical Trials Registration: NCT05145348.

AB - The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age. Clinical Trials Registration: NCT05145348.

KW - antibody response

KW - COVID-19 vaccination

KW - Down syndrome

KW - SARS-CoV-2

KW - Prospective Studies

KW - Humans

KW - Vaccination

KW - Antibodies, Viral

KW - Down Syndrome

KW - BNT162 Vaccine

KW - COVID-19 Vaccines

KW - Antibody Formation

KW - Adult

KW - COVID-19/prevention & control

KW - RNA, Messenger

UR - https://www.scopus.com/pages/publications/85137153699

U2 - 10.1093/infdis/jiac235

DO - 10.1093/infdis/jiac235

M3 - Article

C2 - 35748853

AN - SCOPUS:85137153699

SN - 1537-6613

VL - 226

SP - 673

EP - 677

JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

IS - 4

ER -

Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome

Abstract

Keywords

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