Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization

R. F. Suijkerbuijk; A. Y. Van De Veen; J. Van Echten; C. H.C.M. Buys; B. De Jong; J. W. Oosterhuis; D. A. Warburton; J. J. Cassiman; D. Schonk; A. Geurts Van Kessel

Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization

R. F. Suijkerbuijk
, A. Y. Van De Veen
, J. Van Echten
, C. H.C.M. Buys
, B. De Jong
, J. W. Oosterhuis
, D. A. Warburton
, J. J. Cassiman
, D. Schonk
, A. Geurts Van Kessel

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

The recently developed competitive in situ hybridization (CISH) strategy was applied to the analysis of chromosome 12 aberrations in testicular germ cell tumors (TGCTs). DNAs from two rodent-human somatic cell hybrids, containing either a normal chromosome 12 or the p arm of chromosome 12 as their unique human material, were used as probes. Our results demonstrate a genuine iso-12p character of the standard marker chromosome in TGCTs. Moreover, variant markers were identified representing translocation products that also involve chromosome 12.

Original language	English
Pages (from-to)	269-273
Number of pages	5
Journal	American Journal of Human Genetics
Volume	48
Issue number	2
Publication status	Published - Feb 1991
Externally published	Yes

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Suijkerbuijk, R. F., Van De Veen, A. Y., Van Echten, J., Buys, C. H. C. M., De Jong, B., Oosterhuis, J. W., Warburton, D. A., Cassiman, J. J., Schonk, D., & Geurts Van Kessel, A. (1991). Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization. American Journal of Human Genetics, 48(2), 269-273.

@article{ec97906a06b442bda2b84e55830cd1e0,

title = "Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization",

abstract = "The recently developed competitive in situ hybridization (CISH) strategy was applied to the analysis of chromosome 12 aberrations in testicular germ cell tumors (TGCTs). DNAs from two rodent-human somatic cell hybrids, containing either a normal chromosome 12 or the p arm of chromosome 12 as their unique human material, were used as probes. Our results demonstrate a genuine iso-12p character of the standard marker chromosome in TGCTs. Moreover, variant markers were identified representing translocation products that also involve chromosome 12.",

author = "Suijkerbuijk, \{R. F.\} and \{Van De Veen\}, \{A. Y.\} and \{Van Echten\}, J. and Buys, \{C. H.C.M.\} and \{De Jong\}, B. and Oosterhuis, \{J. W.\} and Warburton, \{D. A.\} and Cassiman, \{J. J.\} and D. Schonk and \{Geurts Van Kessel\}, A.",

year = "1991",

month = feb,

language = "English",

volume = "48",

pages = "269--273",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "2",

}

Suijkerbuijk, RF, Van De Veen, AY, Van Echten, J, Buys, CHCM, De Jong, B, Oosterhuis, JW, Warburton, DA, Cassiman, JJ, Schonk, D & Geurts Van Kessel, A 1991, 'Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization', American Journal of Human Genetics, vol. 48, no. 2, pp. 269-273.

Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization. / Suijkerbuijk, R. F.; Van De Veen, A. Y.; Van Echten, J. et al.
In: American Journal of Human Genetics, Vol. 48, No. 2, 02.1991, p. 269-273.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization

AU - Suijkerbuijk, R. F.

AU - Van De Veen, A. Y.

AU - Van Echten, J.

AU - Buys, C. H.C.M.

AU - De Jong, B.

AU - Oosterhuis, J. W.

AU - Warburton, D. A.

AU - Cassiman, J. J.

AU - Schonk, D.

AU - Geurts Van Kessel, A.

PY - 1991/2

Y1 - 1991/2

N2 - The recently developed competitive in situ hybridization (CISH) strategy was applied to the analysis of chromosome 12 aberrations in testicular germ cell tumors (TGCTs). DNAs from two rodent-human somatic cell hybrids, containing either a normal chromosome 12 or the p arm of chromosome 12 as their unique human material, were used as probes. Our results demonstrate a genuine iso-12p character of the standard marker chromosome in TGCTs. Moreover, variant markers were identified representing translocation products that also involve chromosome 12.

AB - The recently developed competitive in situ hybridization (CISH) strategy was applied to the analysis of chromosome 12 aberrations in testicular germ cell tumors (TGCTs). DNAs from two rodent-human somatic cell hybrids, containing either a normal chromosome 12 or the p arm of chromosome 12 as their unique human material, were used as probes. Our results demonstrate a genuine iso-12p character of the standard marker chromosome in TGCTs. Moreover, variant markers were identified representing translocation products that also involve chromosome 12.

UR - https://www.scopus.com/pages/publications/0026078816

M3 - Article

C2 - 1846721

AN - SCOPUS:0026078816

SN - 0002-9297

VL - 48

SP - 269

EP - 273

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 2

ER -