Desmoplastic infantile ganglioglioma with a malignant course

Eelco W Hoving; Johan M Kros; Ellis Groninger; Wilfred F A den Dunnen

doi:10.3171/PED-08/01/095

Desmoplastic infantile ganglioglioma with a malignant course

Eelco W Hoving, Johan M Kros, Ellis Groninger, Wilfred F A den Dunnen

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.

Original language	English
Pages (from-to)	95-8
Number of pages	4
Journal	Journal of Neurosurgery. Pediatrics
Volume	1
Issue number	1
DOIs	https://doi.org/10.3171/PED-08/01/095
Publication status	Published - Jan 2008
Externally published	Yes

Keywords

Ganglioglioma/metabolism
Glial Fibrillary Acidic Protein/metabolism
Humans
Infant
Ki-67 Antigen/metabolism
Magnetic Resonance Imaging
Male
Neoplasm Recurrence, Local
Neoplasm Staging
Neurosurgical Procedures/methods
Supratentorial Neoplasms/metabolism
Ubiquitin-Protein Ligases/metabolism

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10.3171/PED-08/01/095

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title = "Desmoplastic infantile ganglioglioma with a malignant course",

abstract = "Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.",

keywords = "Ganglioglioma/metabolism, Glial Fibrillary Acidic Protein/metabolism, Humans, Infant, Ki-67 Antigen/metabolism, Magnetic Resonance Imaging, Male, Neoplasm Recurrence, Local, Neoplasm Staging, Neurosurgical Procedures/methods, Supratentorial Neoplasms/metabolism, Ubiquitin-Protein Ligases/metabolism",

author = "Hoving, {Eelco W} and Kros, {Johan M} and Ellis Groninger and {den Dunnen}, {Wilfred F A}",

year = "2008",

month = jan,

doi = "10.3171/PED-08/01/095",

language = "English",

volume = "1",

pages = "95--8",

journal = "Journal of Neurosurgery. Pediatrics",

issn = "1933-0707",

publisher = "American Association of Neurological Surgeons",

number = "1",

}

TY - JOUR

T1 - Desmoplastic infantile ganglioglioma with a malignant course

AU - Hoving, Eelco W

AU - Kros, Johan M

AU - Groninger, Ellis

AU - den Dunnen, Wilfred F A

PY - 2008/1

Y1 - 2008/1

N2 - Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.

AB - Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.

KW - Ganglioglioma/metabolism

KW - Glial Fibrillary Acidic Protein/metabolism

KW - Humans

KW - Infant

KW - Ki-67 Antigen/metabolism

KW - Magnetic Resonance Imaging

KW - Male

KW - Neoplasm Recurrence, Local

KW - Neoplasm Staging

KW - Neurosurgical Procedures/methods

KW - Supratentorial Neoplasms/metabolism

KW - Ubiquitin-Protein Ligases/metabolism

U2 - 10.3171/PED-08/01/095

DO - 10.3171/PED-08/01/095

M3 - Article

C2 - 18352812

SN - 1933-0707

VL - 1

SP - 95

EP - 98

JO - Journal of Neurosurgery. Pediatrics

JF - Journal of Neurosurgery. Pediatrics

IS - 1

ER -

Desmoplastic infantile ganglioglioma with a malignant course

Abstract

Keywords

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