TY - JOUR
T1 - Determinants of quality of life during induction therapy in pediatric acute lymphoblastic leukemia
AU - van Litsenburg, Raphaële R.L.
AU - Huisman, Jaap
AU - Pieters, Rob
AU - Verhaak, Chris
AU - Kaspers, Gertjan J.L.
AU - Gemke, Reinoud J.B.J.
N1 - Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.
PY - 2014/12
Y1 - 2014/12
N2 - Purpose: Improvement in survival of pediatric acute lymphoblastic leukemia (ALL) has increased the attention to quality of life (QoL). QoL is impaired during maintenance treatment, but little is known about QoL during induction therapy. Identification of patients with poor QoL during induction will provide opportunities for early interventions, and may subsequently improve future QoL. This national multi-center study aimed to assess QoL and its determinants during ALL induction treatment.Methods: Proxy reports of the Child Health Questionnaire (CHQ) and the PedsQL cancer version were collected. Child, treatment, and parental characteristics were analyzed as potential determinants in a multiple regression model.Results: One hundred thirty parents of children participated (response rate 82 %), median child age was 5.7 years and 48 % were female. QoL, as measured with the CHQ, was significantly lower than the norm, the effect sizes were large, and the differences were clinically relevant. Physical QoL was more often affected than psychosocial QoL. Regression models could be constructed for 4/ 10 CHQ scales and 6/ 8 PedsQL cancer scales, accounting for 7 to 36 % of the variance in scores. Impaired QoL was most often associated with older children, girls, and time since diagnosis. Also, father respondents seem to have a lower QoL perception compared to mother respondents although this needs to be confirmed in future research.Conclusions: Specific counseling for subsets of patients with a higher risk of low QoL during the early phases of therapy is warranted.
AB - Purpose: Improvement in survival of pediatric acute lymphoblastic leukemia (ALL) has increased the attention to quality of life (QoL). QoL is impaired during maintenance treatment, but little is known about QoL during induction therapy. Identification of patients with poor QoL during induction will provide opportunities for early interventions, and may subsequently improve future QoL. This national multi-center study aimed to assess QoL and its determinants during ALL induction treatment.Methods: Proxy reports of the Child Health Questionnaire (CHQ) and the PedsQL cancer version were collected. Child, treatment, and parental characteristics were analyzed as potential determinants in a multiple regression model.Results: One hundred thirty parents of children participated (response rate 82 %), median child age was 5.7 years and 48 % were female. QoL, as measured with the CHQ, was significantly lower than the norm, the effect sizes were large, and the differences were clinically relevant. Physical QoL was more often affected than psychosocial QoL. Regression models could be constructed for 4/ 10 CHQ scales and 6/ 8 PedsQL cancer scales, accounting for 7 to 36 % of the variance in scores. Impaired QoL was most often associated with older children, girls, and time since diagnosis. Also, father respondents seem to have a lower QoL perception compared to mother respondents although this needs to be confirmed in future research.Conclusions: Specific counseling for subsets of patients with a higher risk of low QoL during the early phases of therapy is warranted.
KW - Acute lymphoblastic leukemia
KW - Cancer
KW - Childhood
KW - Oncology
KW - Pediatric
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=84929942566&partnerID=8YFLogxK
U2 - 10.1007/s00520-014-2349-2
DO - 10.1007/s00520-014-2349-2
M3 - Article
C2 - 25011520
AN - SCOPUS:84929942566
SN - 0941-4355
VL - 22
SP - 3235
EP - 3242
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 12
ER -