@article{976aef04ac7545468117d80f2809f86d,
title = "Dissecting the regulatory circuitry of a eukaryotic genome",
abstract = "Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast. Components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were found to have roles in expression of distinct sets of genes. The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific transcription factors, a novel mechanism for coordinate regulation of specific sets of genes when cells encounter limiting nutrients, and evidence that the ultimate targets of signal transduction pathways can be identified within the initiation apparatus.",
author = "Holstege, \{Frank C.P.\} and Jennings, \{Ezra G.\} and Wyrick, \{John J.\} and Lee, \{Tong Ihn\} and Hengartner, \{Christoph J.\} and Green, \{Michael R.\} and Golub, \{Todd R.\} and Lander, \{Eric S.\} and Young, \{Richard A.\}",
note = "Funding Information: We are grateful to Gwen Acton, Gerry Fink, Tim Galitski, Nancy Hannett, David Hartemink, Fran Lewitter, Hiten Madhani, Johnny Park, Steve Rozen, Michael Sayre, Kevin Struhl, Pablo Tamayo, Joachim Theilhaber, and Elizabeth Winzeler for helpful discussion, comments on the manuscript, suggestions for the web site, and software support. We thank David Allis, Gerard Faye, Young-Joon Kim, Craig Peterson, and Michael Sayre for reagents, and are particularly grateful to Vic Myer for providing the tagged Srb10 strain. This work was supported by funds from the NIH, Bristol-Myers Squibb Company, Affymetrix Inc., and Millennium Pharmaceuticals Inc. F. C. P. H. was supported by fellowships from EMBO and the Human Frontier Science Program; E. G. J. is a predoctoral fellow of the Howard Hughes Medical Institute; and J. J. W. is a predoctoral fellow of the National Science Foundation. T. R. G. is a recipient of a Burroughs-Wellcome Fund Career Award in the Biomedical Sciences.",
year = "1998",
month = nov,
day = "25",
doi = "10.1016/S0092-8674(00)81641-4",
language = "English",
volume = "95",
pages = "717--728",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "5",
}