Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: A call for standardization

Hester N. Blufpand; Nicole Hes; Arend Bökenkamp; Marianne D. Van de Wetering; Gertjan J.L. Kaspers

doi:10.1002/pbc.24572

Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: A call for standardization

Hester N. Blufpand, Nicole Hes, Arend Bökenkamp, Marianne D. Van de Wetering, Gertjan J.L. Kaspers

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Despite changes in survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. To provide cutting-edge care for children with cancer oncologist must be familiar with their nephrotoxic potential. Careful monitoring of renal function during treatment is therefore indicated. Well-defined guidelines for this are lacking. We reviewed current DCOG protocols and showed that monitoring of renal function during treatment varies widely between protocols. In some protocols recommended renal function measures are inappropriate given the chemotherapy prescribed. Advices on dose modifications in case of renal dysfunction also vary, even with comparable regimens. These differences are unwanted and call for standardization.

Original language	English
Pages (from-to)	337-344
Number of pages	8
Journal	Pediatric Blood and Cancer
Volume	61
Issue number	2
DOIs	https://doi.org/10.1002/pbc.24572
Publication status	Published - Feb 2014
Externally published	Yes

Keywords

Adverse effects
Chemotherapy induced nephrotoxicity
Childhood cancer
Dose modifications in case of renal dysfunction
Renal function

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10.1002/pbc.24572

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title = "Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: A call for standardization",

abstract = "Despite changes in survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. To provide cutting-edge care for children with cancer oncologist must be familiar with their nephrotoxic potential. Careful monitoring of renal function during treatment is therefore indicated. Well-defined guidelines for this are lacking. We reviewed current DCOG protocols and showed that monitoring of renal function during treatment varies widely between protocols. In some protocols recommended renal function measures are inappropriate given the chemotherapy prescribed. Advices on dose modifications in case of renal dysfunction also vary, even with comparable regimens. These differences are unwanted and call for standardization.",

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AU - Blufpand, Hester N.

AU - Hes, Nicole

AU - Bökenkamp, Arend

AU - Van de Wetering, Marianne D.

AU - Kaspers, Gertjan J.L.

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AB - Despite changes in survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. To provide cutting-edge care for children with cancer oncologist must be familiar with their nephrotoxic potential. Careful monitoring of renal function during treatment is therefore indicated. Well-defined guidelines for this are lacking. We reviewed current DCOG protocols and showed that monitoring of renal function during treatment varies widely between protocols. In some protocols recommended renal function measures are inappropriate given the chemotherapy prescribed. Advices on dose modifications in case of renal dysfunction also vary, even with comparable regimens. These differences are unwanted and call for standardization.

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Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: A call for standardization

Abstract

Keywords

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