Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review

L. T. Warris, M. M. Van den Heuvel-Eibrink, M. A.H. den Hoed, F. K. Aarsen, R. Pieters, E. L.T. van den Akker

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)

Abstract

Steroid-induced neuropsychological side effects impact quality of life in children with acute lymphoblastic leukemia. Dexamethasone induces more metabolic side effects than prednisone. To evaluate whether dexamethasone also leads to more neuropsychological side effects, we reviewed all available literature. Randomized controlled trials with neuropsychological function as the primary or secondary outcome did not show clinically meaningful differences between dexamethasone and prednisone on cognition, mood or behavior. Pediatr Blood Cancer 2014;61:1313-1318.

Original languageEnglish
Pages (from-to)1313-1318
Number of pages6
JournalPediatric Blood and Cancer
Volume61
Issue number7
DOIs
Publication statusPublished - Jul 2014
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • Corticosteroids
  • Neuropsychological
  • Pediatrics
  • Psychological

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