Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis.

Kristel M.L. Crommentuyn; Jan W. Mulder; Rolf W. Sparidans; Alwin D.R. Huitema; Jan H.M. Schellens; Jos H. Beijnen

doi:10.1086/382675

Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis.

Kristel M.L. Crommentuyn
, Jan W. Mulder
, Rolf W. Sparidans
, Alwin D.R. Huitema
, Jan H.M. Schellens
, Jos H. Beijnen

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

We describe a drug-drug interaction between coformulated lopinavir/ritonavir and itraconazole in a patient infected with human immunodeficiency virus type 1 who had disseminated histoplasmosis. Coadministration of these agents led to a strong increase in itraconazole concentrations and a decrease in concentrations of its metabolite, hydroxyitraconazole, which is equally active pharmacologically. The dosage of itraconazole was reduced when it was used in combination with lopinavir/ritonavir.

Original language	English
Pages (from-to)	e73-75
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	38
Issue number	8
DOIs	https://doi.org/10.1086/382675
Publication status	Published - 15 Apr 2004
Externally published	Yes

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Crommentuyn, K. M. L., Mulder, J. W., Sparidans, R. W., Huitema, A. D. R., Schellens, J. H. M., & Beijnen, J. H. (2004). Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 38(8), e73-75. https://doi.org/10.1086/382675

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title = "Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis.",

abstract = "We describe a drug-drug interaction between coformulated lopinavir/ritonavir and itraconazole in a patient infected with human immunodeficiency virus type 1 who had disseminated histoplasmosis. Coadministration of these agents led to a strong increase in itraconazole concentrations and a decrease in concentrations of its metabolite, hydroxyitraconazole, which is equally active pharmacologically. The dosage of itraconazole was reduced when it was used in combination with lopinavir/ritonavir.",

author = "Crommentuyn, \{Kristel M.L.\} and Mulder, \{Jan W.\} and Sparidans, \{Rolf W.\} and Huitema, \{Alwin D.R.\} and Schellens, \{Jan H.M.\} and Beijnen, \{Jos H.\}",

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month = apr,

day = "15",

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language = "English",

volume = "38",

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journal = "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",

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Crommentuyn, KML, Mulder, JW, Sparidans, RW, Huitema, ADR, Schellens, JHM & Beijnen, JH 2004, 'Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis.', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 38, no. 8, pp. e73-75. https://doi.org/10.1086/382675

Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis. / Crommentuyn, Kristel M.L.; Mulder, Jan W.; Sparidans, Rolf W. et al.
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 38, No. 8, 15.04.2004, p. e73-75.

Research output: Contribution to journal › Article › peer-review

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AU - Mulder, Jan W.

AU - Sparidans, Rolf W.

AU - Huitema, Alwin D.R.

AU - Schellens, Jan H.M.

AU - Beijnen, Jos H.

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AB - We describe a drug-drug interaction between coformulated lopinavir/ritonavir and itraconazole in a patient infected with human immunodeficiency virus type 1 who had disseminated histoplasmosis. Coadministration of these agents led to a strong increase in itraconazole concentrations and a decrease in concentrations of its metabolite, hydroxyitraconazole, which is equally active pharmacologically. The dosage of itraconazole was reduced when it was used in combination with lopinavir/ritonavir.

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Crommentuyn KML, Mulder JW, Sparidans RW, Huitema ADR, Schellens JHM, Beijnen JH. Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2004 Apr 15;38(8):e73-75. doi: 10.1086/382675

Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis.

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