Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Idoya Lahortiga; Kim De Keersmaecker; Pieter Van Vlierberghe; Carlos Graux; Barbara Cauwelier; Frederic Lambert; Nicole Mentens; H. Berna Beverloo; Rob Pieters; Frank Speleman; Maria D. Odero; Marijke Bauters; Guy Froyen; Peter Marynen; Peter Vandenberghe; Iwona Wlodarska; Jules P.P. Meijerink; Jan Cools

doi:10.1038/ng2025

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Idoya Lahortiga
, Kim De Keersmaecker
, Pieter Van Vlierberghe
, Carlos Graux
, Barbara Cauwelier
, Frederic Lambert
, Nicole Mentens
, H. Berna Beverloo
, Rob Pieters
, Frank Speleman
, Maria D. Odero
, Marijke Bauters
, Guy Froyen
, Peter Marynen
, Peter Vandenberghe
, Iwona Wlodarska
, Jules P.P. Meijerink
, Jan Cools

Research output: Contribution to journal › Article › peer-review

232 Citations (Scopus)

Abstract

We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

Original language	English
Pages (from-to)	593-595
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	5
DOIs	https://doi.org/10.1038/ng2025
Publication status	Published - May 2007
Externally published	Yes

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10.1038/ng2025

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Lahortiga, I., De Keersmaecker, K., Van Vlierberghe, P., Graux, C., Cauwelier, B., Lambert, F., Mentens, N., Beverloo, H. B., Pieters, R., Speleman, F., Odero, M. D., Bauters, M., Froyen, G., Marynen, P., Vandenberghe, P., Wlodarska, I., Meijerink, J. P. P., & Cools, J. (2007). Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nature Genetics, 39(5), 593-595. https://doi.org/10.1038/ng2025

@article{847ff42abeb742849c7b389bc45ceadf,

title = "Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia",

abstract = "We identified a duplication of the MYB oncogene in 8.4\% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.",

author = "Idoya Lahortiga and \{De Keersmaecker\}, Kim and \{Van Vlierberghe\}, Pieter and Carlos Graux and Barbara Cauwelier and Frederic Lambert and Nicole Mentens and Beverloo, \{H. Berna\} and Rob Pieters and Frank Speleman and Odero, \{Maria D.\} and Marijke Bauters and Guy Froyen and Peter Marynen and Peter Vandenberghe and Iwona Wlodarska and Meijerink, \{Jules P.P.\} and Jan Cools",

note = "Funding Information: This work was supported by grants from the Foundation Against Cancer (a public interest foundation) (J.C.), the Fonds voor Wetenschappelijk Onderzoek (FWO)-Vlaanderen (P.M., F.S.), the Interuniversity Attraction Poles granted by the Belgian Federal Office for Scientific, Technical and Cultural Affairs, a Jos{\'e} Carreras fellowship from the European Hematology Association (J.C.), Concerted Research Action grant 12051203 (F.S.), the Sophia Foundation for Medical Research (SSWO-404, P.V.V.), the Spanish Association Against Cancer (I.L., M.D.O.) and a Concerted Research Action Grant from K.U. Leuven (J.C., P.V., I.W., P.M.). I.L. is a visiting postdoctoral researcher, K.D.K. is an aspirant, J.C. is a postdoctoral researcher and P.V. is a clinical investigator of the FWO-Vlaanderen. M.B. is funded by the Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT-Vlaanderen).",

year = "2007",

month = may,

doi = "10.1038/ng2025",

language = "English",

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pages = "593--595",

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Lahortiga, I, De Keersmaecker, K, Van Vlierberghe, P, Graux, C, Cauwelier, B, Lambert, F, Mentens, N, Beverloo, HB, Pieters, R, Speleman, F, Odero, MD, Bauters, M, Froyen, G, Marynen, P, Vandenberghe, P, Wlodarska, I, Meijerink, JPP & Cools, J 2007, 'Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia', Nature Genetics, vol. 39, no. 5, pp. 593-595. https://doi.org/10.1038/ng2025

TY - JOUR

T1 - Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

AU - Lahortiga, Idoya

AU - De Keersmaecker, Kim

AU - Van Vlierberghe, Pieter

AU - Graux, Carlos

AU - Cauwelier, Barbara

AU - Lambert, Frederic

AU - Mentens, Nicole

AU - Beverloo, H. Berna

AU - Pieters, Rob

AU - Speleman, Frank

AU - Odero, Maria D.

AU - Bauters, Marijke

AU - Froyen, Guy

AU - Marynen, Peter

AU - Vandenberghe, Peter

AU - Wlodarska, Iwona

AU - Meijerink, Jules P.P.

AU - Cools, Jan

N1 - Funding Information: This work was supported by grants from the Foundation Against Cancer (a public interest foundation) (J.C.), the Fonds voor Wetenschappelijk Onderzoek (FWO)-Vlaanderen (P.M., F.S.), the Interuniversity Attraction Poles granted by the Belgian Federal Office for Scientific, Technical and Cultural Affairs, a José Carreras fellowship from the European Hematology Association (J.C.), Concerted Research Action grant 12051203 (F.S.), the Sophia Foundation for Medical Research (SSWO-404, P.V.V.), the Spanish Association Against Cancer (I.L., M.D.O.) and a Concerted Research Action Grant from K.U. Leuven (J.C., P.V., I.W., P.M.). I.L. is a visiting postdoctoral researcher, K.D.K. is an aspirant, J.C. is a postdoctoral researcher and P.V. is a clinical investigator of the FWO-Vlaanderen. M.B. is funded by the Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT-Vlaanderen).

PY - 2007/5

Y1 - 2007/5

N2 - We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

AB - We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

UR - https://www.scopus.com/pages/publications/34247641748

U2 - 10.1038/ng2025

DO - 10.1038/ng2025

M3 - Article

C2 - 17435759

AN - SCOPUS:34247641748

SN - 1061-4036

VL - 39

SP - 593

EP - 595

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Abstract

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