Durable clearance of hepatitis B virus after allogeneic blood stem cell transplantation by adoptive immunity transfer and antiviral chemotherapy

Andreas H. Groll, Margit Baumann-Köhler, Beate Storkebaum, Joachim Kühn, Heribert Jürgens, Josef Vormoor

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Carriers of hepatitis B virus (HBV) who require allogeneic hematopoietic stem cell transplantation are at increased risk of hepatic morbidity and mortality. We report the course of a 12-year-old female hepatitis B surface antigen (HBsAg)- and hepatitis B envelope antigen (HBeAg)-positive HBV carrier with acute lymphoblastic leukemia who cleared HBV after successful allogeneic blood stem cell transplantation from an anti-hepatitis B surface antibody- and anti-hepatitis B core antibody-positive, HLA-identical sibling and preemptive antiviral therapy with lamivudine. This case demonstrates that durable clearance of longstanding HBV infection can be safely achieved by antiviral chemotherapy and adoptive immunity transfer from a naturally immune matched related donor.

Original languageEnglish
Pages (from-to)753-755
Number of pages3
JournalPediatric Infectious Disease Journal
Volume22
Issue number8
DOIs
Publication statusPublished - 1 Aug 2003
Externally publishedYes

Keywords

  • Hepatitis B
  • Immunity transfer
  • Lamivudine
  • Marrow transplantation

Fingerprint

Dive into the research topics of 'Durable clearance of hepatitis B virus after allogeneic blood stem cell transplantation by adoptive immunity transfer and antiviral chemotherapy'. Together they form a unique fingerprint.

Cite this