Abstract
Carriers of hepatitis B virus (HBV) who require allogeneic hematopoietic stem cell transplantation are at increased risk of hepatic morbidity and mortality. We report the course of a 12-year-old female hepatitis B surface antigen (HBsAg)- and hepatitis B envelope antigen (HBeAg)-positive HBV carrier with acute lymphoblastic leukemia who cleared HBV after successful allogeneic blood stem cell transplantation from an anti-hepatitis B surface antibody- and anti-hepatitis B core antibody-positive, HLA-identical sibling and preemptive antiviral therapy with lamivudine. This case demonstrates that durable clearance of longstanding HBV infection can be safely achieved by antiviral chemotherapy and adoptive immunity transfer from a naturally immune matched related donor.
Original language | English |
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Pages (from-to) | 753-755 |
Number of pages | 3 |
Journal | Pediatric Infectious Disease Journal |
Volume | 22 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1 Aug 2003 |
Externally published | Yes |
Keywords
- Hepatitis B
- Immunity transfer
- Lamivudine
- Marrow transplantation