EANM-EORTC general recommendations for sentinel node diagnostics in melanoma

Annette H. Chakera, Birger Hesse, Zeynep Burak, James R. Ballinger, Allan Britten, Corrado Caracò, Alistair J. Cochran, Martin G. Cook, Krzysztof T. Drzewiecki, Richard Essner, Einat Even-Sapir, Alexander M.M. Eggermont, Tanja Gmeiner Stopar, Christian Ingvar, Martin C. Mihm, Stanley W. McCarthy, Nicola Mozzillo, Omgo E. Nieweg, Richard A. Scolyer, Hans StarzJohn F. Thompson, Giuseppe Trifirò, Giuseppe Viale, Sergi Vidal-Sicart, Roger Uren, Wendy Waddington, Arturo Chiti, Alain Spatz, Alessandro Testori

Research output: Contribution to journalReview articlepeer-review

159 Citations (Scopus)


The accurate diagnosis of a sentinel node in melanoma includes a sequence of procedures from different medical specialities (nuclear medicine, surgery, oncology, and pathology). The items covered are presented in 11 sections and a reference list: (1) definition of a sentinel node, (2) clinical indications, (3) radiopharmaceuticals and activity injected, (4) dosimetry, (5) injection technique, (6) image acquisition and interpretation, (7) report and display, (8) use of dye, (9) gamma probe detection, (10) surgical techniques in sentinel node biopsy, and (11) pathological evaluation of melanoma-draining sentinel lymph nodes. If specific recommendations given cannot be based on evidence from original, scientific studies, referral is given to "general consensus" and similar expressions. The recommendations are designed to assist in the practice of referral to, performance, interpretation and reporting of all steps of the sentinel node procedure in the hope of setting state-of-the-art standards for good-quality evaluation of possible spread to the lymphatic system in intermediate-to-high risk melanoma without clinical signs of dissemination.

Original languageEnglish
Pages (from-to)1713-1742
Number of pages30
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number10
Publication statusPublished - 2009
Externally publishedYes


  • Blue dye
  • Gamma probe
  • Lymphoscintigraphy
  • Melanoma
  • Pathology
  • Sentinel node


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