Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia

Wendy A G Stams; Monique L den Boer; H Berna Beverloo; Karin M Kazemier; Elisabeth R van Wering; Gritta E Janka-Schaub; Rob Pieters

Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia

Wendy A G Stams, Monique L den Boer, H Berna Beverloo, Karin M Kazemier, Elisabeth R van Wering, Gritta E Janka-Schaub, Rob Pieters

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The fusion protein TEL-AML1 in t(12;21)+ acute lymphoblastic leukemia (ALL) recruits co-repressors and histone deacetylases (HDAC), which transrepress AML1 target genes. Normal bone marrow cells were more resistant to HDAC inhibitor FK228 induced cell killing than were cells from ALL patients with or without t(12;21). FK228 induced differentiation in ALL, irrespective of the presence of t(12;21).

Original language	English
Pages (from-to)	1697-9
Number of pages	3
Journal	Haematologica
Volume	90
Issue number	12
Publication status	Published - Dec 2005
Externally published	Yes

Keywords

Antibiotics, Antineoplastic/pharmacology
Antigens, Differentiation, B-Lymphocyte/analysis
Antineoplastic Agents/pharmacology
Asparaginase/pharmacology
B-Lymphocytes/drug effects
Bone Marrow Cells/drug effects
Butyrates/pharmacology
Cell Differentiation/drug effects
Core Binding Factor Alpha 2 Subunit/analysis
Depsipeptides/pharmacology
Histone Deacetylase Inhibitors
Humans
Myeloid Cells/drug effects
Oncogene Proteins, Fusion/analysis
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/enzymology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology
Tumor Cells, Cultured/drug effects

Cite this

@article{1d3fd65e03324d1d969a5e69c921e2c2,

title = "Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia",

abstract = "The fusion protein TEL-AML1 in t(12;21)+ acute lymphoblastic leukemia (ALL) recruits co-repressors and histone deacetylases (HDAC), which transrepress AML1 target genes. Normal bone marrow cells were more resistant to HDAC inhibitor FK228 induced cell killing than were cells from ALL patients with or without t(12;21). FK228 induced differentiation in ALL, irrespective of the presence of t(12;21).",

keywords = "Antibiotics, Antineoplastic/pharmacology, Antigens, Differentiation, B-Lymphocyte/analysis, Antineoplastic Agents/pharmacology, Asparaginase/pharmacology, B-Lymphocytes/drug effects, Bone Marrow Cells/drug effects, Butyrates/pharmacology, Cell Differentiation/drug effects, Core Binding Factor Alpha 2 Subunit/analysis, Depsipeptides/pharmacology, Histone Deacetylase Inhibitors, Humans, Myeloid Cells/drug effects, Oncogene Proteins, Fusion/analysis, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/enzymology, Precursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology, Tumor Cells, Cultured/drug effects",

author = "Stams, {Wendy A G} and {den Boer}, {Monique L} and Beverloo, {H Berna} and Kazemier, {Karin M} and {van Wering}, {Elisabeth R} and Janka-Schaub, {Gritta E} and Rob Pieters",

year = "2005",

month = dec,

language = "English",

volume = "90",

pages = "1697--9",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "12",

}

TY - JOUR

T1 - Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia

AU - Stams, Wendy A G

AU - den Boer, Monique L

AU - Beverloo, H Berna

AU - Kazemier, Karin M

AU - van Wering, Elisabeth R

AU - Janka-Schaub, Gritta E

AU - Pieters, Rob

PY - 2005/12

Y1 - 2005/12

N2 - The fusion protein TEL-AML1 in t(12;21)+ acute lymphoblastic leukemia (ALL) recruits co-repressors and histone deacetylases (HDAC), which transrepress AML1 target genes. Normal bone marrow cells were more resistant to HDAC inhibitor FK228 induced cell killing than were cells from ALL patients with or without t(12;21). FK228 induced differentiation in ALL, irrespective of the presence of t(12;21).

AB - The fusion protein TEL-AML1 in t(12;21)+ acute lymphoblastic leukemia (ALL) recruits co-repressors and histone deacetylases (HDAC), which transrepress AML1 target genes. Normal bone marrow cells were more resistant to HDAC inhibitor FK228 induced cell killing than were cells from ALL patients with or without t(12;21). FK228 induced differentiation in ALL, irrespective of the presence of t(12;21).

KW - Antibiotics, Antineoplastic/pharmacology

KW - Antigens, Differentiation, B-Lymphocyte/analysis

KW - Antineoplastic Agents/pharmacology

KW - Asparaginase/pharmacology

KW - B-Lymphocytes/drug effects

KW - Bone Marrow Cells/drug effects

KW - Butyrates/pharmacology

KW - Cell Differentiation/drug effects

KW - Core Binding Factor Alpha 2 Subunit/analysis

KW - Depsipeptides/pharmacology

KW - Histone Deacetylase Inhibitors

KW - Humans

KW - Myeloid Cells/drug effects

KW - Oncogene Proteins, Fusion/analysis

KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/enzymology

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology

KW - Tumor Cells, Cultured/drug effects

M3 - Article

C2 - 16330447

SN - 0390-6078

VL - 90

SP - 1697

EP - 1699

JO - Haematologica

JF - Haematologica

IS - 12

ER -

Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia

Abstract

Keywords

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Cite this