Effects of CIS‐platinum on embryonal carcinoma cell lines in vitro

J. W. Oosterhuis, P. W. Andrews, B. B. Knowles, I. Damjanov

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Human and mouse embryonal carcinoma (EC) cells lines were compared with several cell lines of a more differentiated phenotype for their relative sensitivities to the cytotoxic effects of cis‐platinum (cis‐diamine‐dichloroplatinum; CDDP); EC lines were among the most sensitive. Furthermore, several markers of EC cell differentiation were not induced by CDDP, irrespective of the concentration of the drug used. These data provide an explanation for the relative sensitivity of the EC cells in non‐seminomatous germ‐cell tumors to cis‐platinum therapy.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalInternational Journal of Cancer
Issue number1
Publication statusPublished - 15 Jul 1984
Externally publishedYes


Dive into the research topics of 'Effects of CIS‐platinum on embryonal carcinoma cell lines in vitro'. Together they form a unique fingerprint.

Cite this