Effects of CIS‐platinum on embryonal carcinoma cell lines in vitro

J. W. Oosterhuis; P. W. Andrews; B. B. Knowles; I. Damjanov

doi:10.1002/ijc.2910340123

Effects of CIS‐platinum on embryonal carcinoma cell lines in vitro

J. W. Oosterhuis
, P. W. Andrews
, B. B. Knowles
, I. Damjanov

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Human and mouse embryonal carcinoma (EC) cells lines were compared with several cell lines of a more differentiated phenotype for their relative sensitivities to the cytotoxic effects of cis‐platinum (cis‐diamine‐dichloroplatinum; CDDP); EC lines were among the most sensitive. Furthermore, several markers of EC cell differentiation were not induced by CDDP, irrespective of the concentration of the drug used. These data provide an explanation for the relative sensitivity of the EC cells in non‐seminomatous germ‐cell tumors to cis‐platinum therapy.

Original language	English
Pages (from-to)	133-139
Number of pages	7
Journal	International journal of cancer
Volume	34
Issue number	1
DOIs	https://doi.org/10.1002/ijc.2910340123
Publication status	Published - 15 Jul 1984
Externally published	Yes

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abstract = "Human and mouse embryonal carcinoma (EC) cells lines were compared with several cell lines of a more differentiated phenotype for their relative sensitivities to the cytotoxic effects of cis‐platinum (cis‐diamine‐dichloroplatinum; CDDP); EC lines were among the most sensitive. Furthermore, several markers of EC cell differentiation were not induced by CDDP, irrespective of the concentration of the drug used. These data provide an explanation for the relative sensitivity of the EC cells in non‐seminomatous germ‐cell tumors to cis‐platinum therapy.",

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AU - Damjanov, I.

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AB - Human and mouse embryonal carcinoma (EC) cells lines were compared with several cell lines of a more differentiated phenotype for their relative sensitivities to the cytotoxic effects of cis‐platinum (cis‐diamine‐dichloroplatinum; CDDP); EC lines were among the most sensitive. Furthermore, several markers of EC cell differentiation were not induced by CDDP, irrespective of the concentration of the drug used. These data provide an explanation for the relative sensitivity of the EC cells in non‐seminomatous germ‐cell tumors to cis‐platinum therapy.

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Effects of CIS‐platinum on embryonal carcinoma cell lines in vitro

Abstract

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