TY - JOUR
T1 - EndoCompass project
T2 - Research roadmap for pituitary and neuroendocrine tumor endocrinology
AU - Castano, Justo P.
AU - Dattani, Mehul Tulsidas
AU - Grozinsky-Glasberg, Simona
AU - Karavitaki, Niki
AU - Pavel, Marianne E.
AU - Andoniadou, Cynthia
AU - Alexandraki, Krystallenia
AU - Capatina, Cristina
AU - Cerbone, Manuela
AU - Ferone, Diego
AU - Gan, Hoong Wei
AU - Hofland, Johannes
AU - Hofland, Leo J.
AU - Ibanez-Costa, Alejandro
AU - Ilie, Mirela Diana
AU - Isidori, Andrea M.
AU - Korbonits, Marta
AU - Kos-Kudła, Beata
AU - Maghnie, Mohamad
AU - Mantovani, Giovanna
AU - Marazuela, Monica
AU - Raverot, Gerald
AU - Scarpa, Aldo
AU - Schilbach, Katharina
AU - Theodoropoulou, Marily
AU - Van Santen, Hanneke M.
AU - Zatelli, Maria Chiara
N1 - © The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.
PY - 2025/10/1
Y1 - 2025/10/1
N2 - BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in pituitary and neuroendocrine tumor endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. RESULTS: Research priorities encompass congenital and acquired disorders, tumor development and progression, and neuroendocrine neoplasms. Key areas include genetic/epigenetic factors, tumor microenvironment, personalized treatment approaches, developing preclinical models, and implementing artificial intelligence. Special emphasis is placed on aggressive tumors, hypothalamic syndromes, and establishing pan-European biobanks and databases. CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into pituitary-neuroendocrine disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.
AB - BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in pituitary and neuroendocrine tumor endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. RESULTS: Research priorities encompass congenital and acquired disorders, tumor development and progression, and neuroendocrine neoplasms. Key areas include genetic/epigenetic factors, tumor microenvironment, personalized treatment approaches, developing preclinical models, and implementing artificial intelligence. Special emphasis is placed on aggressive tumors, hypothalamic syndromes, and establishing pan-European biobanks and databases. CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into pituitary-neuroendocrine disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.
KW - Biomedical Research/trends
KW - Databases, Factual
KW - Endocrinology/trends
KW - European Union
KW - Humans
KW - Neuroendocrine Tumors/therapy
KW - Pituitary Neoplasms/therapy
UR - https://www.scopus.com/pages/publications/105019114177
U2 - 10.1093/ejendo/lvaf035
DO - 10.1093/ejendo/lvaf035
M3 - Review article
C2 - 41104469
AN - SCOPUS:105024736434
SN - 0804-4643
VL - 193
SP - 105
EP - 120
JO - European journal of endocrinology
JF - European journal of endocrinology
IS - Supplement_2
ER -