Endoscopic management of Ewing's sarcoma of ethmoid sinus within the AMORE framework: a new paradigm

Giuseppe Meccariello, Johannes H M Merks, Bradley R Pieters, Wouter R van Furth, Peerooz Saeed, Reineke A Schoot, Nicole J M Freling, Johannes Bras, Simon D Strackee, Alfons J M Balm, Christos Georgalas

Research output: Contribution to journalArticlepeer-review


The Ablative surgery, MOulage brachytherapy and REconstruction) (AMORE) protocol developed in the Academic Medical Center of Amsterdam has been used successfully to treat sarcomas. The use of endoscopic surgery fits well within this framework. A 6-year-old boy presented with Ewing Sarcoma of left ethmoid sinus closest to orbit. The patient underwent neoadjuvant chemotherapy followed by complete endoscopic resection, brachytherapy and reconstruction. Brachytherapy was administered by iridium catheters through limited Lynch-Howarth incision. Skull base defect was reconstructed with a galea flap. The use of endoscopic surgery complemented by neoadjuvant chemotherapy and brachytherapy might maximize tumor control while reducing morbidity.

Original languageEnglish
Pages (from-to)139-43
Number of pages5
JournalInternational journal of pediatric otorhinolaryngology
Issue number1
Publication statusPublished - Jan 2013
Externally publishedYes


  • Bone Neoplasms/diagnosis
  • Brachytherapy/methods
  • Chemoradiotherapy/methods
  • Child
  • Combined Modality Therapy
  • Endoscopy/methods
  • Ethmoid Sinus
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging/methods
  • Male
  • Neoadjuvant Therapy/methods
  • Reconstructive Surgical Procedures/methods
  • Sarcoma, Ewing/diagnosis
  • Treatment Outcome


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