EphB/EphrinB receptors and Wnt signaling in colorectal cancer

Hans Clevers, Eduard Batlle

Research output: Contribution to journalReview articlepeer-review

132 Citations (Scopus)

Abstract

Eph receptors and their ephrin ligands mediate cell repulsion during embryonic development. In the intestinal epithelium, EphB receptors are Wnt signaling target genes that control cell compartmentalization along the crypt axis. Recent findings have shown that this family of receptors are key players during colorectal cancer progression. Here, we review the current knowledge of the EphB/ephrinB system in the intestinal epithelium and we discuss their tumor suppressor role in the context of the multistep progression of colorectal cancer.

Original languageEnglish
Pages (from-to)2-5
Number of pages4
JournalCancer Research
Volume66
Issue number1
DOIs
Publication statusPublished - 1 Jan 2006
Externally publishedYes

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