@article{6dfce6ce298040ad8b8896a8f75205b0,
title = "Epidemiology of leukaemia and lymphoma in children and young adults from the north of England, 1990-2002",
abstract = "Aim: We aimed to describe and contrast the epidemiology of haematological malignancies among 0-14 and 15-24-year-olds in northern England from 1990 to 2002 and compare clinical trial entry by age group. Patients and methods: Incidence rates were examined by age, sex and period of diagnosis and differences were tested using Poisson regression. Differences and trends in survival were assessed using Cox regression. Results: 1680 subjects were included comprising 948 leukaemias and 732 lymphomas. Incidence rates for acute lymphoblastic leukaemia were significantly higher for 0-14 compared to 15-24-year-olds, whilst Hodgkin lymphoma showed the reverse. No significant changes in incidence were observed. 60\% of leukaemia patients aged 15-24 years entered trials compared to 92\% of 0-14-year-olds. Survival rates were significantly lower and improved less markedly over time for 15-24 compared to 0-14-year-olds, particularly for leukaemia. Conclusions: Trial accrual rates need to be improved amongst 15-24-year-olds and a more structured follow-up approach adopted for this unique population.",
keywords = "Children, Epidemiology, Survival, Teenage, Young adult",
author = "Feltbower, \{Richard G.\} and McNally, \{Richard J.Q.\} and Kinsey, \{Sally E.\} and Lewis, \{Ian J.\} and Picton, \{Susan V.\} and Proctor, \{Stephen J.\} and Michael Richards and Geoff Shenton and Rod Skinner and Stark, \{Daniel P.\} and Josef Vormoor and Windebank, \{Kevin P.\} and McKinney, \{Patricia A.\}",
note = "Funding Information: We are grateful to Paula McLoughlin, Margaret Buchan, Lorna More and Claire Hamilton for data collection and the co-operation of all paediatric oncologists, physicians and General Practitioners in Yorkshire and the Northern Regions. We acknowledge the efforts of the national trials units who exerted a huge amount of effort to ensure that our trials data were complete, especially Sue Richards and Julie Burrett at the Clinical Trial Service Unit in Oxford, Elizabeth Sellwood and Andrew Howman from the University of Birmingham Trials Unit and Paul Smith at the UCL Cancer Trials Centre. Finally, we thank the Candlelighters Trust and Newcastle Hospitals NHS Trust for supporting the costs of running the Yorkshire and the Northern Region cancer registers over the last three decades; and the North of England Children{\textquoteright}s Cancer Research Fund for supporting childhood cancer research at Newcastle University.",
year = "2009",
month = feb,
doi = "10.1016/j.ejca.2008.09.020",
language = "English",
volume = "45",
pages = "420--427",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Ltd.",
number = "3",
}