Epigenome data release: A participant-centered approach to privacy protection

Stephanie O.M. Dyke, Warren A. Cheung, Yann Joly, Ole Ammerpohl, Pavlo Lutsik, Mark A. Rothstein, Maxime Caron, Stephan Busche, Guillaume Bourque, Lars Rönnblom, Paul Flicek, Stephan Beck, Martin Hirst, Henk Stunnenberg, Reiner Siebert, Jörn Walter, Tomi Pastinen

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.

Original languageEnglish
Article number142
JournalGenome Biology
Issue number1
Publication statusPublished - 17 Jul 2015
Externally publishedYes


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