Epigenome data release: A participant-centered approach to privacy protection

Stephanie O.M. Dyke; Warren A. Cheung; Yann Joly; Ole Ammerpohl; Pavlo Lutsik; Mark A. Rothstein; Maxime Caron; Stephan Busche; Guillaume Bourque; Lars Rönnblom; Paul Flicek; Stephan Beck; Martin Hirst; Henk Stunnenberg; Reiner Siebert; Jörn Walter; Tomi Pastinen

doi:10.1186/s13059-015-0723-0

Epigenome data release: A participant-centered approach to privacy protection

Stephanie O.M. Dyke
, Warren A. Cheung
, Yann Joly
, Ole Ammerpohl
, Pavlo Lutsik
, Mark A. Rothstein
, Maxime Caron
, Stephan Busche
, Guillaume Bourque
, Lars Rönnblom
, Paul Flicek
, Stephan Beck
, Martin Hirst
, Henk Stunnenberg
, Reiner Siebert
, Jörn Walter
, Tomi Pastinen

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.

Original language	English
Article number	142
Journal	Genome biology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s13059-015-0723-0
Publication status	Published - 17 Jul 2015
Externally published	Yes

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10.1186/s13059-015-0723-0

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Dyke, S. O. M., Cheung, W. A., Joly, Y., Ammerpohl, O., Lutsik, P., Rothstein, M. A., Caron, M., Busche, S., Bourque, G., Rönnblom, L., Flicek, P., Beck, S., Hirst, M., Stunnenberg, H., Siebert, R., Walter, J., & Pastinen, T. (2015). Epigenome data release: A participant-centered approach to privacy protection. Genome biology, 16(1), Article 142. https://doi.org/10.1186/s13059-015-0723-0

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doi = "10.1186/s13059-015-0723-0",

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AU - Dyke, Stephanie O.M.

AU - Cheung, Warren A.

AU - Joly, Yann

AU - Ammerpohl, Ole

AU - Lutsik, Pavlo

AU - Rothstein, Mark A.

AU - Caron, Maxime

AU - Busche, Stephan

AU - Bourque, Guillaume

AU - Rönnblom, Lars

AU - Flicek, Paul

AU - Beck, Stephan

AU - Hirst, Martin

AU - Stunnenberg, Henk

AU - Siebert, Reiner

AU - Walter, Jörn

AU - Pastinen, Tomi

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AB - Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.

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SN - 1474-7596

VL - 16

JO - Genome biology

JF - Genome biology

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ER -

Epigenome data release: A participant-centered approach to privacy protection

Abstract

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