Epithelioid hemangioendothelioma in children: The European Pediatric Soft Tissue Sarcoma Study Group experience

Daniel Orbach, Max Van Noesel, Bernadette Brennan, Nadège Corradini, Rita Alaggio, Myriam Ben Arush, Reineke A Schoot, Pablo Berlanga, Ilaria Zanetti, Lisa Lyngsie Hjalgrim, Federica Di Corti, Gema Ramirez, Michela Casanova, Andrea Ferrari

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The European pediatric Soft tissue sarcoma Study Group analyzed all children with epithelioid hemangioendothelioma prospectively registered in the NRSTS-05 (EUDRACT 2005-001139-31) and in MTS-2008 (NCT00379457) studies: 10 patients with localized and one with metastatic disease. Median age was 14.3 years (range, 9.0-18.8). Local therapy was initial primary surgery in seven cases, and five patients received systemic therapy. No patients received radiotherapy. After a median follow-up of 50 months (range, 6-176) for living patients, nine patients remain alive off therapy and two died. Five-year progression free and overall survivals are, respectively, 77.1% (95% confidence interval [CI]: 34.5-93.9) and 74.1% (95% CI: 28.1-93.0).

Original languageEnglish
Pages (from-to)e29882
JournalPediatric blood & cancer
Volume69
Issue number10
Early online date16 Jul 2022
DOIs
Publication statusPublished - Oct 2022

Keywords

  • Clinical Studies as Topic
  • Sarcoma/pathology
  • Humans
  • Adolescent
  • Soft Tissue Neoplasms/pathology
  • Hemangioendothelioma, Epithelioid/therapy
  • Child

Fingerprint

Dive into the research topics of 'Epithelioid hemangioendothelioma in children: The European Pediatric Soft Tissue Sarcoma Study Group experience'. Together they form a unique fingerprint.

Cite this