EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: A case report

Uta Flucke; Thomas Mentzel; Marian A. Verdijk; Pieter J. Slootweg; David H. Creytens; Albert J.H. Suurmeijer; Bastiaan B.J. Tops

doi:10.1016/j.humpath.2011.08.004

EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: A case report

Uta Flucke, Thomas Mentzel, Marian A. Verdijk, Pieter J. Slootweg, David H. Creytens, Albert J.H. Suurmeijer, Bastiaan B.J. Tops

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Abstract

Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue myoepithelioma arising in the pelvis with an EWSR1-ATF1 fusion, therefore extending the spectrum of partner genes of EWSR1. In addition, this case indicates that there are overlapping genetic features of myoepithelial tumors, clear cell sarcoma, angiomatoid fibrous histiocytoma, and hyalinizing clear-cell carcinoma of the salivary gland.

Original language	English
Pages (from-to)	764-768
Number of pages	5
Journal	Human Pathology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1016/j.humpath.2011.08.004
Publication status	Published - May 2012
Externally published	Yes

Keywords

EWSR1-ATF1 fusion
Myoepithelial tumor
Soft tissue

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10.1016/j.humpath.2011.08.004

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title = "EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: A case report",

abstract = "Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue myoepithelioma arising in the pelvis with an EWSR1-ATF1 fusion, therefore extending the spectrum of partner genes of EWSR1. In addition, this case indicates that there are overlapping genetic features of myoepithelial tumors, clear cell sarcoma, angiomatoid fibrous histiocytoma, and hyalinizing clear-cell carcinoma of the salivary gland.",

keywords = "EWSR1-ATF1 fusion, Myoepithelial tumor, Soft tissue",

author = "Uta Flucke and Thomas Mentzel and Verdijk, {Marian A.} and Slootweg, {Pieter J.} and Creytens, {David H.} and Suurmeijer, {Albert J.H.} and Tops, {Bastiaan B.J.}",

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T2 - A case report

AU - Flucke, Uta

AU - Mentzel, Thomas

AU - Verdijk, Marian A.

AU - Slootweg, Pieter J.

AU - Creytens, David H.

AU - Suurmeijer, Albert J.H.

AU - Tops, Bastiaan B.J.

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AB - Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue myoepithelioma arising in the pelvis with an EWSR1-ATF1 fusion, therefore extending the spectrum of partner genes of EWSR1. In addition, this case indicates that there are overlapping genetic features of myoepithelial tumors, clear cell sarcoma, angiomatoid fibrous histiocytoma, and hyalinizing clear-cell carcinoma of the salivary gland.

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EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: A case report

Abstract

Keywords

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