Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Wim J E Tissing, Melchior Lauten, Jules P P Meijerink, Monique L den Boer, Jan Willem Koper, Peter Sonneveld, Rob Pieters

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.

Original languageEnglish
Pages (from-to)1279-81
Number of pages3
JournalHaematologica
Volume90
Issue number9
Publication statusPublished - Sept 2005
Externally publishedYes

Keywords

  • Child
  • Cohort Studies
  • Drug Resistance, Neoplasm/genetics
  • Gene Expression Regulation/drug effects
  • Glucocorticoids/biosynthesis
  • Humans
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
  • Prednisolone/therapeutic use
  • Protein Isoforms/biosynthesis
  • Receptors, Glucocorticoid/biosynthesis

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