Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Wim J E Tissing; Melchior Lauten; Jules P P Meijerink; Monique L den Boer; Jan Willem Koper; Peter Sonneveld; Rob Pieters

Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Wim J E Tissing
, Melchior Lauten
, Jules P P Meijerink
, Monique L den Boer
, Jan Willem Koper
, Peter Sonneveld
, Rob Pieters

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.

Original language	English
Pages (from-to)	1279-81
Number of pages	3
Journal	Haematologica
Volume	90
Issue number	9
Publication status	Published - Sept 2005
Externally published	Yes

Keywords

Child
Cohort Studies
Drug Resistance, Neoplasm/genetics
Gene Expression Regulation/drug effects
Glucocorticoids/biosynthesis
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
Prednisolone/therapeutic use
Protein Isoforms/biosynthesis
Receptors, Glucocorticoid/biosynthesis

Cite this

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title = "Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia",

abstract = "In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.",

keywords = "Child, Cohort Studies, Drug Resistance, Neoplasm/genetics, Gene Expression Regulation/drug effects, Glucocorticoids/biosynthesis, Humans, Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Prednisolone/therapeutic use, Protein Isoforms/biosynthesis, Receptors, Glucocorticoid/biosynthesis",

author = "Tissing, \{Wim J E\} and Melchior Lauten and Meijerink, \{Jules P P\} and \{den Boer\}, \{Monique L\} and Koper, \{Jan Willem\} and Peter Sonneveld and Rob Pieters",

year = "2005",

month = sep,

language = "English",

volume = "90",

pages = "1279--81",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "9",

}

TY - JOUR

T1 - Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

AU - Tissing, Wim J E

AU - Lauten, Melchior

AU - Meijerink, Jules P P

AU - den Boer, Monique L

AU - Koper, Jan Willem

AU - Sonneveld, Peter

AU - Pieters, Rob

PY - 2005/9

Y1 - 2005/9

N2 - In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.

AB - In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.

KW - Child

KW - Cohort Studies

KW - Drug Resistance, Neoplasm/genetics

KW - Gene Expression Regulation/drug effects

KW - Glucocorticoids/biosynthesis

KW - Humans

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy

KW - Prednisolone/therapeutic use

KW - Protein Isoforms/biosynthesis

KW - Receptors, Glucocorticoid/biosynthesis

M3 - Article

C2 - 16154856

SN - 0390-6078

VL - 90

SP - 1279

EP - 1281

JO - Haematologica

JF - Haematologica

IS - 9

ER -

Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Abstract

Keywords

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Cite this