Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging

Marieke van de Ven; Jaan Olle Andressoo; Valerie B. Holcomb; Paul Hasty; Yousin Suh; Harry van Steeg; George A. Garinis; Jan H.J. Hoeijmakers; James R. Mitchell

doi:10.1016/j.mad.2006.11.011

Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging

Marieke van de Ven
, Jaan Olle Andressoo
, Valerie B. Holcomb
, Paul Hasty
, Yousin Suh
, Harry van Steeg
, George A. Garinis
, Jan H.J. Hoeijmakers
, James R. Mitchell

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.

Original language	English
Pages (from-to)	58-63
Number of pages	6
Journal	Mechanisms of Ageing and Development
Volume	128
Issue number	1
DOIs	https://doi.org/10.1016/j.mad.2006.11.011
Publication status	Published - Jan 2007
Externally published	Yes

Keywords

Adaptive stress response
Ageing
Base excision repair
DNA damage
Nucleotide excision repair
Progeria
SIRT6

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10.1016/j.mad.2006.11.011

Cite this

van de Ven, M., Andressoo, J. O., Holcomb, V. B., Hasty, P., Suh, Y., van Steeg, H., Garinis, G. A., Hoeijmakers, J. H. J., & Mitchell, J. R. (2007). Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging. Mechanisms of Ageing and Development, 128(1), 58-63. https://doi.org/10.1016/j.mad.2006.11.011

@article{24c9ab1b8cb24c93a2e4a645749d4ad5,

title = "Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging",

abstract = "Semantic distinctions between {"}normal{"} aging, {"}pathological{"} aging (or age-related disease) and {"}premature{"} aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.",

keywords = "Adaptive stress response, Ageing, Base excision repair, DNA damage, Nucleotide excision repair, Progeria, SIRT6",

author = "\{van de Ven\}, Marieke and Andressoo, \{Jaan Olle\} and Holcomb, \{Valerie B.\} and Paul Hasty and Yousin Suh and \{van Steeg\}, Harry and Garinis, \{George A.\} and Hoeijmakers, \{Jan H.J.\} and Mitchell, \{James R.\}",

note = "Funding Information: The authors would like to thank Joris Pothof, David Lombard and Raul Mostoslavsky for informative discussions and critical reading of the manuscript. This work was supported in part by the following grants: National Institutes of Health (1PO1 AG17242-02), Association of International Cancer Research Grant Award (05-280), and Netherlands Organization for Health Research and Development, Research Institute for Diseases in the Elderly (60-60400-98-004).",

year = "2007",

month = jan,

doi = "10.1016/j.mad.2006.11.011",

language = "English",

volume = "128",

pages = "58--63",

journal = "Mechanisms of Ageing and Development",

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publisher = "Elsevier Ireland Ltd",

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van de Ven, M, Andressoo, JO, Holcomb, VB, Hasty, P, Suh, Y, van Steeg, H, Garinis, GA, Hoeijmakers, JHJ & Mitchell, JR 2007, 'Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging', Mechanisms of Ageing and Development, vol. 128, no. 1, pp. 58-63. https://doi.org/10.1016/j.mad.2006.11.011

TY - JOUR

T1 - Extended longevity mechanisms in short-lived progeroid mice

T2 - Identification of a preservative stress response associated with successful aging

AU - van de Ven, Marieke

AU - Andressoo, Jaan Olle

AU - Holcomb, Valerie B.

AU - Hasty, Paul

AU - Suh, Yousin

AU - van Steeg, Harry

AU - Garinis, George A.

AU - Hoeijmakers, Jan H.J.

AU - Mitchell, James R.

N1 - Funding Information: The authors would like to thank Joris Pothof, David Lombard and Raul Mostoslavsky for informative discussions and critical reading of the manuscript. This work was supported in part by the following grants: National Institutes of Health (1PO1 AG17242-02), Association of International Cancer Research Grant Award (05-280), and Netherlands Organization for Health Research and Development, Research Institute for Diseases in the Elderly (60-60400-98-004).

PY - 2007/1

Y1 - 2007/1

N2 - Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.

AB - Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.

KW - Adaptive stress response

KW - Ageing

KW - Base excision repair

KW - DNA damage

KW - Nucleotide excision repair

KW - Progeria

KW - SIRT6

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M3 - Article

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AN - SCOPUS:33846211383

SN - 0047-6374

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JF - Mechanisms of Ageing and Development

IS - 1

ER -

Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging

Abstract

Keywords

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