Fanconi anemia (cross)linked to DNA repair

Laura J. Niedernhofer; Astrid S. Lalai; Jan H.J. Hoeijmakers

doi:10.1016/j.cell.2005.12.009

Fanconi anemia (cross)linked to DNA repair

Laura J. Niedernhofer
, Astrid S. Lalai
, Jan H.J. Hoeijmakers

Research output: Contribution to journal › Review article › peer-review

258 Citations (Scopus)

Abstract

Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.

Original language	English
Pages (from-to)	1191-1198
Number of pages	8
Journal	Cell
Volume	123
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2005.12.009
Publication status	Published - 29 Dec 2005
Externally published	Yes

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10.1016/j.cell.2005.12.009

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@article{0f356d37de024fd58f98de54fa57b347,

title = "Fanconi anemia (cross)linked to DNA repair",

abstract = "Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.",

author = "Niedernhofer, \{Laura J.\} and Lalai, \{Astrid S.\} and Hoeijmakers, \{Jan H.J.\}",

note = "Funding Information: We apologize for the limited number of references due to space limitations. A.S.L. and J.H.J.H. are supported by the Dutch Cancer Society, the EC, the NIH, and the Netherlands Organization for Scientific Research (NWO). L.J.N. is supported by the University of Pittsburgh Cancer Institute and the NCI (K22-CA111525).",

year = "2005",

month = dec,

day = "29",

doi = "10.1016/j.cell.2005.12.009",

language = "English",

volume = "123",

pages = "1191--1198",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "7",

}

TY - JOUR

T1 - Fanconi anemia (cross)linked to DNA repair

AU - Niedernhofer, Laura J.

AU - Lalai, Astrid S.

AU - Hoeijmakers, Jan H.J.

N1 - Funding Information: We apologize for the limited number of references due to space limitations. A.S.L. and J.H.J.H. are supported by the Dutch Cancer Society, the EC, the NIH, and the Netherlands Organization for Scientific Research (NWO). L.J.N. is supported by the University of Pittsburgh Cancer Institute and the NCI (K22-CA111525).

PY - 2005/12/29

Y1 - 2005/12/29

N2 - Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.

AB - Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.

UR - https://www.scopus.com/pages/publications/29244489543

U2 - 10.1016/j.cell.2005.12.009

DO - 10.1016/j.cell.2005.12.009

M3 - Review article

C2 - 16377561

AN - SCOPUS:29244489543

SN - 0092-8674

VL - 123

SP - 1191

EP - 1198

JO - Cell

JF - Cell

IS - 7

ER -

Fanconi anemia (cross)linked to DNA repair

Abstract

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