Fibronectin is a hypoxia-independent target of the tumor suppressor VHL

Hans A.R. Bluyssen, Martijn P.J.K. Lolkema, Moniek Van Beest, Michelle Boone, Cristel M.J.T. Snijckers, Maartje Los, Martijn F.B.G. Gebbink, Branko Braam, Frank C.P. Holstege, Rachel H. Giles, Emile E. Voest

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

The von Hippel-Lindau (VHL) tumor suppressor gene regulates the extracellular matrix by controlling fibronectin deposition. To identify novel VHL target genes, we subjected mRNA from VHL-deficient RCC cells (786-0-pRC) and a transfectant re-expressing wildtype VHL (786-0-VHL) to differential expression profiling. Among the differentially expressed genes, we detected that fibronectin is upregulated in the presence of VHL, while it is not affected by hypoxia. Thus regulation of fibronectin deposition by VHL occurs at the transcriptional level, irrespective of oxygen levels.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalFEBS Letters
Volume556
Issue number1-3
DOIs
Publication statusPublished - 2 Jan 2004
Externally publishedYes

Keywords

  • Fibronectin
  • Hypoxia
  • Microarray
  • Renal cell carcinoma
  • VHL

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