Flucloxacillin results in suboptimal plasma voriconazole concentrations

Eline W. Muilwijk; Bart G.J. Dekkers; Stefanie S.V. Henriet; Paul E. Verweij; Bregje Witjes; Astrid M.L. Oude Lashof; Geert H. Groeneveld; Johannes Van Der Hoeven; Jan Willem C. Alffenaar; Frans G.M. Russel; Frank Van De Veerdonk; Roger J.M. Brüggemann

doi:10.1128/AAC.00915-17

Flucloxacillin results in suboptimal plasma voriconazole concentrations

Eline W. Muilwijk
, Bart G.J. Dekkers
, Stefanie S.V. Henriet
, Paul E. Verweij
, Bregje Witjes
, Astrid M.L. Oude Lashof
, Geert H. Groeneveld
, Johannes Van Der Hoeven
, Jan Willem C. Alffenaar
, Frans G.M. Russel
, Frank Van De Veerdonk
, Roger J.M. Brüggemann

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.

Original language	English
Article number	e00915-17
Journal	Antimicrobial agents and chemotherapy
Volume	61
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00915-17
Publication status	Published - Sept 2017
Externally published	Yes

Keywords

Aspergillosis
Drug interactions
Exposure
Influenza
Pharmacokinetics

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10.1128/AAC.00915-17

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Muilwijk, E. W., Dekkers, B. G. J., Henriet, S. S. V., Verweij, P. E., Witjes, B., Oude Lashof, A. M. L., Groeneveld, G. H., Van Der Hoeven, J., Alffenaar, J. W. C., Russel, F. G. M., Van De Veerdonk, F., & Brüggemann, R. J. M. (2017). Flucloxacillin results in suboptimal plasma voriconazole concentrations. Antimicrobial agents and chemotherapy, 61(9), Article e00915-17. https://doi.org/10.1128/AAC.00915-17

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title = "Flucloxacillin results in suboptimal plasma voriconazole concentrations",

abstract = "Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50\% of patients, that poses a severe threat if not managed properly.",

keywords = "Aspergillosis, Drug interactions, Exposure, Influenza, Pharmacokinetics",

author = "Muilwijk, \{Eline W.\} and Dekkers, \{Bart G.J.\} and Henriet, \{Stefanie S.V.\} and Verweij, \{Paul E.\} and Bregje Witjes and \{Oude Lashof\}, \{Astrid M.L.\} and Groeneveld, \{Geert H.\} and \{Van Der Hoeven\}, Johannes and Alffenaar, \{Jan Willem C.\} and Russel, \{Frans G.M.\} and \{Van De Veerdonk\}, Frank and Br{\"u}ggemann, \{Roger J.M.\}",

year = "2017",

month = sep,

doi = "10.1128/AAC.00915-17",

language = "English",

volume = "61",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Flucloxacillin results in suboptimal plasma voriconazole concentrations

AU - Muilwijk, Eline W.

AU - Dekkers, Bart G.J.

AU - Henriet, Stefanie S.V.

AU - Verweij, Paul E.

AU - Witjes, Bregje

AU - Oude Lashof, Astrid M.L.

AU - Groeneveld, Geert H.

AU - Van Der Hoeven, Johannes

AU - Alffenaar, Jan Willem C.

AU - Russel, Frans G.M.

AU - Van De Veerdonk, Frank

AU - Brüggemann, Roger J.M.

PY - 2017/9

Y1 - 2017/9

N2 - Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.

AB - Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.

KW - Aspergillosis

KW - Drug interactions

KW - Exposure

KW - Influenza

KW - Pharmacokinetics

UR - https://www.scopus.com/pages/publications/85028361026

U2 - 10.1128/AAC.00915-17

DO - 10.1128/AAC.00915-17

M3 - Article

C2 - 28717040

AN - SCOPUS:85028361026

SN - 0066-4804

VL - 61

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 9

M1 - e00915-17

ER -

Flucloxacillin results in suboptimal plasma voriconazole concentrations

Abstract

Keywords

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