Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs

G. J. Peters; J. H. Hooijberg; G. J.L. Kaspers; G. Jansen

doi:10.1016/j.tifs.2005.03.008

Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs

G. J. Peters
, J. H. Hooijberg
, G. J.L. Kaspers
, G. Jansen

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Folates are essential nutrients for the cell for DNA synthesis. From a nutritional perspective, a high folate status may have a beneficial/protective effect against cancer, birth defects and age-related diseases. However, data presented in this study provide evidence that a high folate status can also have a differential impact on the therapeutic efficacy of both folate-based and other widely used anticancer agents. This study describes the molecular mechanisms underlying these effects, which involve folate influx/efflux proteins, intracellular metabolism and target enzymes.

Original language	English
Pages (from-to)	289-297
Number of pages	9
Journal	Trends in Food Science and Technology
Volume	16
Issue number	6-7
DOIs	https://doi.org/10.1016/j.tifs.2005.03.008
Publication status	Published - 2005
Externally published	Yes

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title = "Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs",

abstract = "Folates are essential nutrients for the cell for DNA synthesis. From a nutritional perspective, a high folate status may have a beneficial/protective effect against cancer, birth defects and age-related diseases. However, data presented in this study provide evidence that a high folate status can also have a differential impact on the therapeutic efficacy of both folate-based and other widely used anticancer agents. This study describes the molecular mechanisms underlying these effects, which involve folate influx/efflux proteins, intracellular metabolism and target enzymes.",

author = "Peters, \{G. J.\} and Hooijberg, \{J. H.\} and Kaspers, \{G. J.L.\} and G. Jansen",

note = "Funding Information: Research from the authors was supported by several grants for the Dutch Cancer Society. We also thank Mrs S. van Geloven for secretarial assistance.",

year = "2005",

doi = "10.1016/j.tifs.2005.03.008",

language = "English",

volume = "16",

pages = "289--297",

journal = "Trends in Food Science and Technology",

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TY - JOUR

T1 - Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs

AU - Peters, G. J.

AU - Hooijberg, J. H.

AU - Kaspers, G. J.L.

AU - Jansen, G.

N1 - Funding Information: Research from the authors was supported by several grants for the Dutch Cancer Society. We also thank Mrs S. van Geloven for secretarial assistance.

PY - 2005

Y1 - 2005

N2 - Folates are essential nutrients for the cell for DNA synthesis. From a nutritional perspective, a high folate status may have a beneficial/protective effect against cancer, birth defects and age-related diseases. However, data presented in this study provide evidence that a high folate status can also have a differential impact on the therapeutic efficacy of both folate-based and other widely used anticancer agents. This study describes the molecular mechanisms underlying these effects, which involve folate influx/efflux proteins, intracellular metabolism and target enzymes.

AB - Folates are essential nutrients for the cell for DNA synthesis. From a nutritional perspective, a high folate status may have a beneficial/protective effect against cancer, birth defects and age-related diseases. However, data presented in this study provide evidence that a high folate status can also have a differential impact on the therapeutic efficacy of both folate-based and other widely used anticancer agents. This study describes the molecular mechanisms underlying these effects, which involve folate influx/efflux proteins, intracellular metabolism and target enzymes.

UR - https://www.scopus.com/pages/publications/20444442019

U2 - 10.1016/j.tifs.2005.03.008

DO - 10.1016/j.tifs.2005.03.008

M3 - Article

AN - SCOPUS:20444442019

SN - 0924-2244

VL - 16

SP - 289

EP - 297

JO - Trends in Food Science and Technology

JF - Trends in Food Science and Technology

IS - 6-7

ER -

Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs

Abstract

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