FoxM1 is required for execution of the mitotic programme and chromosome stability

Jamila Laoukili, Matthijs R.H. Kooistra, Alexandra Brás, Jos Kauw, Ron M. Kerkhoven, Ashby Morrison, Hans Clevers, René H. Medema

Research output: Contribution to journalArticlepeer-review

673 Citations (Scopus)

Abstract

Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of subsequent cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 regulates expression of many G2-specific genes and is essential for chromosome stability. Loss of FoxM1 leads to pleiotropic cell-cycle defects, including a delay in G2, chromosome mis-segregation and frequent failure of cytokinesis. We show that transcriptional activation of cyclin B by FoxM1 is essential for timely mitotic entry, whereas CENP-F, another direct target of FoxM1 identified here, is essential for precise functioning of the mitotic spindle checkpoint. Thus, our data uncover a transcriptional cluster regulated by FoxM1 that is essential for proper mitotic progression.

Original languageEnglish
Pages (from-to)126-136
Number of pages11
JournalNature Cell Biology
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes

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