Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C. Jackling, Michael Milevskiy, François Vaillant, Bianca D. Capaldo, Fusheng Guo, Kevin H. Liu, Anne C. Rios, Nicholas Lim, Andrew J. Kueh, David M. Virshup, Marco J. Herold, Haley O. Tucker, Gordon K. Smyth, Geoffrey J. Lindeman, Jane E. Visvader

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.

Original languageEnglish
Pages (from-to)629-644.e8
JournalDevelopmental Cell
Volume47
Issue number5
DOIs
Publication statusPublished - 3 Dec 2018
Externally publishedYes

Keywords

  • Fox transcription factors
  • Foxp1
  • Lgr5
  • mammary gland development
  • mammary stem cell
  • quiescence
  • Tetraspanin
  • Tspan8
  • Wnt

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