Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu; Bhupinder Pal; Yunshun Chen; Felicity C. Jackling; Michael Milevskiy; François Vaillant; Bianca D. Capaldo; Fusheng Guo; Kevin H. Liu; Anne C. Rios; Nicholas Lim; Andrew J. Kueh; David M. Virshup; Marco J. Herold; Haley O. Tucker; Gordon K. Smyth; Geoffrey J. Lindeman; Jane E. Visvader

doi:10.1016/j.devcel.2018.10.001

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C. Jackling, Michael Milevskiy, François Vaillant, Bianca D. Capaldo, Fusheng Guo, Kevin H. Liu, Anne C. Rios, Nicholas Lim, Andrew J. Kueh, David M. Virshup, Marco J. Herold, Haley O. Tucker, Gordon K. Smyth, Geoffrey J. Lindeman, Jane E. Visvader

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.

Original language	English
Pages (from-to)	629-644.e8
Journal	Developmental Cell
Volume	47
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2018.10.001
Publication status	Published - 3 Dec 2018
Externally published	Yes

Keywords

Fox transcription factors
Foxp1
Lgr5
mammary gland development
mammary stem cell
quiescence
Tetraspanin
Tspan8
Wnt

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10.1016/j.devcel.2018.10.001

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Fu, N. Y., Pal, B., Chen, Y., Jackling, F. C., Milevskiy, M., Vaillant, F., Capaldo, B. D., Guo, F., Liu, K. H., Rios, A. C., Lim, N., Kueh, A. J., Virshup, D. M., Herold, M. J., Tucker, H. O., Smyth, G. K., Lindeman, G. J., & Visvader, J. E. (2018). Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence. Developmental Cell, 47(5), 629-644.e8. https://doi.org/10.1016/j.devcel.2018.10.001

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title = "Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence",

abstract = "Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.",

keywords = "Fox transcription factors, Foxp1, Lgr5, mammary gland development, mammary stem cell, quiescence, Tetraspanin, Tspan8, Wnt",

author = "Fu, {Nai Yang} and Bhupinder Pal and Yunshun Chen and Jackling, {Felicity C.} and Michael Milevskiy and Fran{\c c}ois Vaillant and Capaldo, {Bianca D.} and Fusheng Guo and Liu, {Kevin H.} and Rios, {Anne C.} and Nicholas Lim and Kueh, {Andrew J.} and Virshup, {David M.} and Herold, {Marco J.} and Tucker, {Haley O.} and Smyth, {Gordon K.} and Lindeman, {Geoffrey J.} and Visvader, {Jane E.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = dec,

day = "3",

doi = "10.1016/j.devcel.2018.10.001",

language = "English",

volume = "47",

pages = "629--644.e8",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "5",

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Fu, NY, Pal, B, Chen, Y, Jackling, FC, Milevskiy, M, Vaillant, F, Capaldo, BD, Guo, F, Liu, KH, Rios, AC, Lim, N, Kueh, AJ, Virshup, DM, Herold, MJ, Tucker, HO, Smyth, GK, Lindeman, GJ & Visvader, JE 2018, 'Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence', Developmental Cell, vol. 47, no. 5, pp. 629-644.e8. https://doi.org/10.1016/j.devcel.2018.10.001

TY - JOUR

T1 - Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

AU - Fu, Nai Yang

AU - Pal, Bhupinder

AU - Chen, Yunshun

AU - Jackling, Felicity C.

AU - Milevskiy, Michael

AU - Vaillant, François

AU - Capaldo, Bianca D.

AU - Guo, Fusheng

AU - Liu, Kevin H.

AU - Rios, Anne C.

AU - Lim, Nicholas

AU - Kueh, Andrew J.

AU - Virshup, David M.

AU - Herold, Marco J.

AU - Tucker, Haley O.

AU - Smyth, Gordon K.

AU - Lindeman, Geoffrey J.

AU - Visvader, Jane E.

PY - 2018/12/3

Y1 - 2018/12/3

N2 - Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.

AB - Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.

KW - Fox transcription factors

KW - Foxp1

KW - Lgr5

KW - mammary gland development

KW - mammary stem cell

KW - quiescence

KW - Tetraspanin

KW - Tspan8

KW - Wnt

UR - http://www.scopus.com/inward/record.url?scp=85057291875&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2018.10.001

DO - 10.1016/j.devcel.2018.10.001

M3 - Article

C2 - 30523786

AN - SCOPUS:85057291875

SN - 1534-5807

VL - 47

SP - 629-644.e8

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Abstract

Keywords

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