Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

Catherine S. Grasso; Yujie Tang; Nathalene Truffaux; Noah E. Berlow; Lining Liu; Marie-Anne Debily; Michael J. Quist; Lara E. Davis; Elaine C. Huang; Pamelyn J. Woo; Anitha Ponnuswami; Spenser Chen; Tessa B. Johung; Wenchao Sun; Mari Kogiso; Yuchen Du; Lin Qi; Yulun Huang; Marianne Hutt-Cabezas; Katherine E. Warren; Ludivine  Le Dret; Paul S. Meltzer; Hua Mao; Martha Quezado; Dannis G. van Vuurden; Jinu Abraham; Maryam Fouladi; Matthew N. Svalina; Nicholas  Wang; Cytnhia Hawkins; Javad Nazarian; Marta M. Alonso; Eric H. Raabe; Esther Hulleman; Paul T. Spellman; Xiao-Nan Li; Charles Keller; Ranadip Pal; Jacques Grill; Michelle Monje

doi:10.1038/nm.3855

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

Catherine S. Grasso, Yujie Tang, Nathalene Truffaux, Noah E. Berlow, Lining Liu, Marie-Anne Debily, Michael J. Quist, Lara E. Davis, Elaine C. Huang, Pamelyn J. Woo, Anitha Ponnuswami, Spenser Chen, Tessa B. Johung, Wenchao Sun, Mari Kogiso, Yuchen Du, Lin Qi, Yulun Huang, Marianne Hutt-Cabezas, Katherine E. WarrenLudivine Le Dret, Paul S. Meltzer, Hua Mao, Martha Quezado, Dannis G. van Vuurden, Jinu Abraham, Maryam Fouladi, Matthew N. Svalina, Nicholas Wang, Cytnhia Hawkins, Javad Nazarian, Marta M. Alonso, Eric H. Raabe, Esther Hulleman, Paul T. Spellman, Xiao-Nan Li, Charles Keller, Ranadip Pal, Jacques Grill, Michelle Monje

Research output: Contribution to journal › Article › peer-review

474 Citations (Scopus)

Abstract

Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.

Original language	English
Pages (from-to)	55-59
Number of pages	5
Journal	Nature medicine
Volume	21
Issue number	6
DOIs	https://doi.org/10.1038/nm.3855
Publication status	Published - Jun 2015
Externally published	Yes

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Grasso, C. S., Tang, Y., Truffaux, N., Berlow, N. E., Liu, L., Debily, M.-A., Quist, M. J., Davis, L. E., Huang, E. C., Woo, P. J., Ponnuswami, A., Chen, S., Johung, T. B., Sun, W., Kogiso, M., Du, Y., Qi, L., Huang, Y., Hutt-Cabezas, M., ... Monje, M. (2015). Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nature medicine, 21(6), 55-59. https://doi.org/10.1038/nm.3855

@article{b9b43038b7e84b7283c811594d0ba0b8,

title = "Functionally defined therapeutic targets in diffuse intrinsic pontine glioma",

abstract = "Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.",

author = "Grasso, \{Catherine S.\} and Yujie Tang and Nathalene Truffaux and Berlow, \{Noah E.\} and Lining Liu and Marie-Anne Debily and Quist, \{Michael J.\} and Davis, \{Lara E.\} and Huang, \{Elaine C.\} and Woo, \{Pamelyn J.\} and Anitha Ponnuswami and Spenser Chen and Johung, \{Tessa B.\} and Wenchao Sun and Mari Kogiso and Yuchen Du and Lin Qi and Yulun Huang and Marianne Hutt-Cabezas and Warren, \{Katherine E.\} and \{Le Dret\}, Ludivine and Meltzer, \{Paul S.\} and Hua Mao and Martha Quezado and \{van Vuurden\}, \{Dannis G.\} and Jinu Abraham and Maryam Fouladi and Svalina, \{Matthew N.\} and Nicholas Wang and Cytnhia Hawkins and Javad Nazarian and Alonso, \{Marta M.\} and Raabe, \{Eric H.\} and Esther Hulleman and Spellman, \{Paul T.\} and Xiao-Nan Li and Charles Keller and Ranadip Pal and Jacques Grill and Michelle Monje",

year = "2015",

month = jun,

doi = "10.1038/nm.3855",

language = "English",

volume = "21",

pages = "55--59",

journal = "Nature medicine",

issn = "1078-8956",

publisher = "Nature Research",

number = "6",

}

Grasso, CS, Tang, Y, Truffaux, N, Berlow, NE, Liu, L, Debily, M-A, Quist, MJ, Davis, LE, Huang, EC, Woo, PJ, Ponnuswami, A, Chen, S, Johung, TB, Sun, W, Kogiso, M, Du, Y, Qi, L, Huang, Y, Hutt-Cabezas, M, Warren, KE, Le Dret, L, Meltzer, PS, Mao, H, Quezado, M, van Vuurden, DG, Abraham, J, Fouladi, M, Svalina, MN, Wang, N, Hawkins, C, Nazarian, J, Alonso, MM, Raabe, EH, Hulleman, E, Spellman, PT, Li, X-N, Keller, C, Pal, R, Grill, J & Monje, M 2015, 'Functionally defined therapeutic targets in diffuse intrinsic pontine glioma', Nature medicine, vol. 21, no. 6, pp. 55-59. https://doi.org/10.1038/nm.3855

TY - JOUR

T1 - Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

AU - Grasso, Catherine S.

AU - Tang, Yujie

AU - Truffaux, Nathalene

AU - Berlow, Noah E.

AU - Liu, Lining

AU - Debily, Marie-Anne

AU - Quist, Michael J.

AU - Davis, Lara E.

AU - Huang, Elaine C.

AU - Woo, Pamelyn J.

AU - Ponnuswami, Anitha

AU - Chen, Spenser

AU - Johung, Tessa B.

AU - Sun, Wenchao

AU - Kogiso, Mari

AU - Du, Yuchen

AU - Qi, Lin

AU - Huang, Yulun

AU - Hutt-Cabezas, Marianne

AU - Warren, Katherine E.

AU - Le Dret, Ludivine

AU - Meltzer, Paul S.

AU - Mao, Hua

AU - Quezado, Martha

AU - van Vuurden, Dannis G.

AU - Abraham, Jinu

AU - Fouladi, Maryam

AU - Svalina, Matthew N.

AU - Wang, Nicholas

AU - Hawkins, Cytnhia

AU - Nazarian, Javad

AU - Alonso, Marta M.

AU - Raabe, Eric H.

AU - Hulleman, Esther

AU - Spellman, Paul T.

AU - Li, Xiao-Nan

AU - Keller, Charles

AU - Pal, Ranadip

AU - Grill, Jacques

AU - Monje, Michelle

PY - 2015/6

Y1 - 2015/6

N2 - Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.

AB - Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.

UR - https://www.scopus.com/pages/publications/84930764914

U2 - 10.1038/nm.3855

DO - 10.1038/nm.3855

M3 - Article

SN - 1078-8956

VL - 21

SP - 55

EP - 59

JO - Nature medicine

JF - Nature medicine

IS - 6

ER -

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

Abstract

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