TY - JOUR
T1 - Genetic Biomarkers to Identify the Risk of Osteonecrosis in Children with Acute Lymphoblastic Leukemia
AU - den Hoed, Marissa A.H.
AU - Pluijm, Saskia M.F.
AU - Uitterlinden, André G.
AU - Pieters, Rob
AU - van den Heuvel-Eibrink, Marry M.
N1 - Publisher Copyright:
© 2016, Springer International Publishing Switzerland.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Osteonecrosis is a disabling complication of treatment for pediatric acute lymphoblastic leukemia, and much effort has been made to predict which patients are prone to develop this disease. Multiple clinical and genetic factors have already been identified as being associated with osteonecrosis; however, a prediction model that combines pretreatment genetic biomarkers and clinical factors has not yet been designed. Such a prediction model can only be developed with continuing international collaborations and research efforts, including large genome-wide association studies.
AB - Osteonecrosis is a disabling complication of treatment for pediatric acute lymphoblastic leukemia, and much effort has been made to predict which patients are prone to develop this disease. Multiple clinical and genetic factors have already been identified as being associated with osteonecrosis; however, a prediction model that combines pretreatment genetic biomarkers and clinical factors has not yet been designed. Such a prediction model can only be developed with continuing international collaborations and research efforts, including large genome-wide association studies.
UR - http://www.scopus.com/inward/record.url?scp=84976504065&partnerID=8YFLogxK
U2 - 10.1007/s40291-016-0226-z
DO - 10.1007/s40291-016-0226-z
M3 - Article
C2 - 27365083
AN - SCOPUS:84976504065
SN - 1177-1062
VL - 20
SP - 519
EP - 522
JO - Molecular Diagnosis and Therapy
JF - Molecular Diagnosis and Therapy
IS - 6
ER -