Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes

Christine L.E. Siezen; Louis Bont; Hennie M. Hodemaekers; Marieke J. Ermers; Gerda Doornbos; Ruben Vant Slot; Ciska Wijmenga; Hans C.Van Houwelingen; Jan L.L. Kimpen; Tjeerd G. Kimman; Barbara Hoebee; Riny Janssen

doi:10.1097/INF.0b013e31818e2aa9

Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes

Christine L.E. Siezen
, Louis Bont
, Hennie M. Hodemaekers
, Marieke J. Ermers
, Gerda Doornbos
, Ruben Vant Slot
, Ciska Wijmenga
, Hans C.Van Houwelingen
, Jan L.L. Kimpen
, Tjeerd G. Kimman
, Barbara Hoebee
, Riny Janssen

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.

Original language	English
Pages (from-to)	333-335
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	28
Issue number	4
DOIs	https://doi.org/10.1097/INF.0b013e31818e2aa9
Publication status	Published - Apr 2009
Externally published	Yes

Keywords

Bronchiolitis
Host-genetics
Preterm
RSV

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10.1097/INF.0b013e31818e2aa9

Cite this

Siezen, C. L. E., Bont, L., Hodemaekers, H. M., Ermers, M. J., Doornbos, G., Vant Slot, R., Wijmenga, C., Houwelingen, H. C. V., Kimpen, J. L. L., Kimman, T. G., Hoebee, B., & Janssen, R. (2009). Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Pediatric Infectious Disease Journal, 28(4), 333-335. https://doi.org/10.1097/INF.0b013e31818e2aa9

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title = "Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes",

abstract = "Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.",

keywords = "Bronchiolitis, Host-genetics, Preterm, RSV",

author = "Siezen, \{Christine L.E.\} and Louis Bont and Hodemaekers, \{Hennie M.\} and Ermers, \{Marieke J.\} and Gerda Doornbos and \{Vant Slot\}, Ruben and Ciska Wijmenga and Houwelingen, \{Hans C.Van\} and Kimpen, \{Jan L.L.\} and Kimman, \{Tjeerd G.\} and Barbara Hoebee and Riny Janssen",

year = "2009",

month = apr,

doi = "10.1097/INF.0b013e31818e2aa9",

language = "English",

volume = "28",

pages = "333--335",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

Siezen, CLE, Bont, L, Hodemaekers, HM, Ermers, MJ, Doornbos, G, Vant Slot, R, Wijmenga, C, Houwelingen, HCV, Kimpen, JLL, Kimman, TG, Hoebee, B & Janssen, R 2009, 'Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes', Pediatric Infectious Disease Journal, vol. 28, no. 4, pp. 333-335. https://doi.org/10.1097/INF.0b013e31818e2aa9

Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. / Siezen, Christine L.E.; Bont, Louis; Hodemaekers, Hennie M. et al.
In: Pediatric Infectious Disease Journal, Vol. 28, No. 4, 04.2009, p. 333-335.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes

AU - Siezen, Christine L.E.

AU - Bont, Louis

AU - Hodemaekers, Hennie M.

AU - Ermers, Marieke J.

AU - Doornbos, Gerda

AU - Vant Slot, Ruben

AU - Wijmenga, Ciska

AU - Houwelingen, Hans C.Van

AU - Kimpen, Jan L.L.

AU - Kimman, Tjeerd G.

AU - Hoebee, Barbara

AU - Janssen, Riny

PY - 2009/4

Y1 - 2009/4

N2 - Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.

AB - Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.

KW - Bronchiolitis

KW - Host-genetics

KW - Preterm

KW - RSV

UR - https://www.scopus.com/pages/publications/65649136910

U2 - 10.1097/INF.0b013e31818e2aa9

DO - 10.1097/INF.0b013e31818e2aa9

M3 - Article

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AN - SCOPUS:65649136910

SN - 0891-3668

VL - 28

SP - 333

EP - 335

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 4

ER -

Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes

Abstract

Keywords

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