Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Yurii S. Aulchenko; Ilse A. Hoppenbrouwers; Sreeram V. Ramagopalan; Linda Broer; Naghmeh Jafari; Jan Hillert; Jenny Link; Wangko Lundström; Eva Greiner; A. Dessa Sadovnick; Dirk Goossens; Christine Van Broeckhoven; Jurgen Del-Favero; George C. Ebers; Ben A. Oostra; Cornelia M. Van Duijn; Rogier Q. Hintzen

doi:10.1038/ng.251

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Yurii S. Aulchenko
, Ilse A. Hoppenbrouwers
, Sreeram V. Ramagopalan
, Linda Broer
, Naghmeh Jafari
, Jan Hillert
, Jenny Link
, Wangko Lundström
, Eva Greiner
, A. Dessa Sadovnick
, Dirk Goossens
, Christine Van Broeckhoven
, Jurgen Del-Favero
, George C. Ebers
, Ben A. Oostra
, Cornelia M. Van Duijn
, Rogier Q. Hintzen

Research output: Contribution to journal › Article › peer-review

164 Citations (Scopus)

Abstract

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 × 10 ^-10). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

Original language	English
Pages (from-to)	1402-1403
Number of pages	2
Journal	Nature Genetics
Volume	40
Issue number	12
DOIs	https://doi.org/10.1038/ng.251
Publication status	Published - Dec 2008
Externally published	Yes

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Aulchenko, Y. S., Hoppenbrouwers, I. A., Ramagopalan, S. V., Broer, L., Jafari, N., Hillert, J., Link, J., Lundström, W., Greiner, E., Dessa Sadovnick, A., Goossens, D., Van Broeckhoven, C., Del-Favero, J., Ebers, G. C., Oostra, B. A., Van Duijn, C. M., & Hintzen, R. Q. (2008). Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nature Genetics, 40(12), 1402-1403. https://doi.org/10.1038/ng.251

@article{483aff25d0ad49cca903d4bfeb15e18e,

title = "Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis",

abstract = "The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 × 10 -10). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.",

author = "Aulchenko, \{Yurii S.\} and Hoppenbrouwers, \{Ilse A.\} and Ramagopalan, \{Sreeram V.\} and Linda Broer and Naghmeh Jafari and Jan Hillert and Jenny Link and Wangko Lundstr{\"o}m and Eva Greiner and \{Dessa Sadovnick\}, A. and Dirk Goossens and \{Van Broeckhoven\}, Christine and Jurgen Del-Favero and Ebers, \{George C.\} and Oostra, \{Ben A.\} and \{Van Duijn\}, \{Cornelia M.\} and Hintzen, \{Rogier Q.\}",

note = "Funding Information: This study was supported by grants from MS Research Netherlands (R.Q.H. and C.M.v.D.), the Erasmus University Trust Fund, The Netherlands Organisation for Scientific Research (ZON-MW, R.Q.H.), the Erasmus MC and the Multiple Sclerosis Society of Canada Scientific Research Foundation and the Multiple Sclerosis Society of the United Kingdom (S.V.R., G.C.E.). The GRIP study is supported by Centre for Medical Systems Biology (CMSB). The Stockholm part of the study was supported by the Bibbi and Nils Jensen Foundation, by the Swedish Research Council and by the EU project no. LSHM-CT-2005-018637, NeuroproMiSe. We are grateful to all participants and their relatives; general practitioners and neurologists for their contributions; P. Veraart for her help in genealogy; D. Lont and the personnel of the VIB Genetic Service Facility for genotyping; and P. Snijders for his help in data collection.",

year = "2008",

month = dec,

doi = "10.1038/ng.251",

language = "English",

volume = "40",

pages = "1402--1403",

journal = "Nature Genetics",

issn = "1061-4036",

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}

Aulchenko, YS, Hoppenbrouwers, IA, Ramagopalan, SV, Broer, L, Jafari, N, Hillert, J, Link, J, Lundström, W, Greiner, E, Dessa Sadovnick, A, Goossens, D, Van Broeckhoven, C, Del-Favero, J, Ebers, GC, Oostra, BA, Van Duijn, CM & Hintzen, RQ 2008, 'Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis', Nature Genetics, vol. 40, no. 12, pp. 1402-1403. https://doi.org/10.1038/ng.251

TY - JOUR

T1 - Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

AU - Aulchenko, Yurii S.

AU - Hoppenbrouwers, Ilse A.

AU - Ramagopalan, Sreeram V.

AU - Broer, Linda

AU - Jafari, Naghmeh

AU - Hillert, Jan

AU - Link, Jenny

AU - Lundström, Wangko

AU - Greiner, Eva

AU - Dessa Sadovnick, A.

AU - Goossens, Dirk

AU - Van Broeckhoven, Christine

AU - Del-Favero, Jurgen

AU - Ebers, George C.

AU - Oostra, Ben A.

AU - Van Duijn, Cornelia M.

AU - Hintzen, Rogier Q.

N1 - Funding Information: This study was supported by grants from MS Research Netherlands (R.Q.H. and C.M.v.D.), the Erasmus University Trust Fund, The Netherlands Organisation for Scientific Research (ZON-MW, R.Q.H.), the Erasmus MC and the Multiple Sclerosis Society of Canada Scientific Research Foundation and the Multiple Sclerosis Society of the United Kingdom (S.V.R., G.C.E.). The GRIP study is supported by Centre for Medical Systems Biology (CMSB). The Stockholm part of the study was supported by the Bibbi and Nils Jensen Foundation, by the Swedish Research Council and by the EU project no. LSHM-CT-2005-018637, NeuroproMiSe. We are grateful to all participants and their relatives; general practitioners and neurologists for their contributions; P. Veraart for her help in genealogy; D. Lont and the personnel of the VIB Genetic Service Facility for genotyping; and P. Snijders for his help in data collection.

PY - 2008/12

Y1 - 2008/12

N2 - The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 × 10 -10). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

AB - The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 × 10 -10). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

UR - https://www.scopus.com/pages/publications/56749098072

U2 - 10.1038/ng.251

DO - 10.1038/ng.251

M3 - Article

C2 - 18997785

AN - SCOPUS:56749098072

SN - 1061-4036

VL - 40

SP - 1402

EP - 1403

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Abstract

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