Genome maintenance mechanisms for preventing cancer

Research output: Contribution to journalReview articlepeer-review

3290 Citations (Scopus)

Abstract

The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing oncogenesis. During the past decade, knowledge about the mechanisms by which genes erode and the molecular machinery designed to counteract this time-dependent genetic degeneration has increased markedly. At the same time, it has become apparent that inherited or acquired deficiencies in genome maintenance systems contribute significantly to the onset of cancer. This review summarizes the main DNA caretaking systems and their impact on genome stability and carcinogenesis.

Original languageEnglish
Pages (from-to)366-374
Number of pages9
JournalNature
Volume411
Issue number6835
DOIs
Publication statusPublished - 17 May 2001
Externally publishedYes

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