Genome stability, progressive kidney failure and aging

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Two new studies report mutations in FAN1 and three other genome-stability genes that tie the DNA damage response to progressive kidney failure and the dysfunction of several other organs. These findings provide clues to the underlying causes of tissue decline and may add a series of genes to the growing list of genome maintenance factors that protect against premature aging.

Original languageEnglish
Pages (from-to)836-838
Number of pages3
JournalNature Genetics
Issue number8
Publication statusPublished - Aug 2012
Externally publishedYes


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