Genome stability, progressive kidney failure and aging

Hannes Lans; Jan H.J. Hoeijmakers

doi:10.1038/ng.2363

Genome stability, progressive kidney failure and aging

Hannes Lans
, Jan H.J. Hoeijmakers

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Two new studies report mutations in FAN1 and three other genome-stability genes that tie the DNA damage response to progressive kidney failure and the dysfunction of several other organs. These findings provide clues to the underlying causes of tissue decline and may add a series of genes to the growing list of genome maintenance factors that protect against premature aging.

Original language	English
Pages (from-to)	836-838
Number of pages	3
Journal	Nature Genetics
Volume	44
Issue number	8
DOIs	https://doi.org/10.1038/ng.2363
Publication status	Published - Aug 2012
Externally published	Yes

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Genome stability, progressive kidney failure and aging

Abstract

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