Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

S. Saeed; C. Logie; H. G. Stunnenberg; J. H.A. Martens

doi:10.1038/sj.bjc.6606095

Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

S. Saeed, C. Logie, H. G. Stunnenberg, J. H.A. Martens

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.

Original language	English
Pages (from-to)	554-558
Number of pages	5
Journal	British Journal of Cancer
Volume	104
Issue number	4
DOIs	https://doi.org/10.1038/sj.bjc.6606095
Publication status	Published - 15 Feb 2011
Externally published	Yes

Keywords

epigenome
PML-RARa
PU.1 (SPI1)
RXR

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title = "Genome-wide functions of PML-RARα in acute promyelocytic leukaemia",

abstract = "PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.",

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AU - Logie, C.

AU - Stunnenberg, H. G.

AU - Martens, J. H.A.

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AB - PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.

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Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

Abstract

Keywords

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