Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

S. Saeed, C. Logie, H. G. Stunnenberg, J. H.A. Martens

Research output: Contribution to journalReview articlepeer-review

54 Citations (Scopus)

Abstract

PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.

Original languageEnglish
Pages (from-to)554-558
Number of pages5
JournalBritish Journal of Cancer
Volume104
Issue number4
DOIs
Publication statusPublished - 15 Feb 2011
Externally publishedYes

Keywords

  • epigenome
  • PML-RARa
  • PU.1 (SPI1)
  • RXR

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