Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

S. Saeed; C. Logie; H. G. Stunnenberg; J. H.A. Martens

doi:10.1038/sj.bjc.6606095

Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

S. Saeed
, C. Logie
, H. G. Stunnenberg
, J. H.A. Martens

Research output: Contribution to journal › Review article › peer-review

61 Citations (Scopus)

Abstract

PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.

Original language	English
Pages (from-to)	554-558
Number of pages	5
Journal	British journal of cancer
Volume	104
Issue number	4
DOIs	https://doi.org/10.1038/sj.bjc.6606095
Publication status	Published - 15 Feb 2011
Externally published	Yes

Keywords

PML-RARa
PU.1 (SPI1)
RXR
epigenome

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10.1038/sj.bjc.6606095

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title = "Genome-wide functions of PML-RARα in acute promyelocytic leukaemia",

abstract = "PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10\% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.",

keywords = "PML-RARa, PU.1 (SPI1), RXR, epigenome",

author = "S. Saeed and C. Logie and Stunnenberg, \{H. G.\} and Martens, \{J. H.A.\}",

note = "Funding Information: This work was supported by the European Union LSHC-CT-2005-518417 {\textquoteleft}Epitron{\textquoteright} and the Dutch Cancer Foundation (KWF KUN 2009-4527) and Higher Education Commission of Pakistan.",

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AU - Saeed, S.

AU - Logie, C.

AU - Stunnenberg, H. G.

AU - Martens, J. H.A.

N1 - Funding Information: This work was supported by the European Union LSHC-CT-2005-518417 ‘Epitron’ and the Dutch Cancer Foundation (KWF KUN 2009-4527) and Higher Education Commission of Pakistan.

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Y1 - 2011/2/15

N2 - PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.

AB - PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.

KW - PML-RARa

KW - PU.1 (SPI1)

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KW - epigenome

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M3 - Review article

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AN - SCOPUS:79951681879

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SP - 554

EP - 558

JO - British journal of cancer

JF - British journal of cancer

IS - 4

ER -

Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

Abstract

Keywords

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